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In our study, FOXD2\u2010AS1 expression has been found to be upregulated in cutaneous melanoma tissue specimens and cell lines compared with that in normal tissue specimens and normal human epidermal melanocyte, respectively. Furthermore, high expression of FOXD2\u2010AS1 was obviously correlated with deep Breslow thickness, present ulceration, high Clark level and distant metastasis in cutaneous melanoma patients. However, there were no statistical associations between FOXD2\u2010AS1 expression and cutaneous melanoma patients\u2019 disease\u2010free survival and overall survival. The results of loss\u2010of\u2010function study showed that inhibition of FOXD2\u2010AS1 suppresses cutaneous melanoma cell proliferation, migration and invasion through regulating phospho\u2010Akt expression. In conclusion, FOXD2\u2010AS1 is associated with clinical progression in cutaneous melanoma patients, and functions as oncogenic lncRNA in cutaneous melanoma cells.<\/jats:p>","DOI":"10.1002\/jcb.27820","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T04:55:09Z","timestamp":1542171309000},"page":"5417-5423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["FOXD2\u2010AS1 correlates with the malignant status and regulates cell proliferation, migration, and invasion in cutaneous melanoma"],"prefix":"10.1002","volume":"120","author":[{"given":"Wenqing","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Dermatology Xi'an No. 3 Hospital Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zirong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Eighth Hospital of Xi'an Xi'an 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