{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T20:16:45Z","timestamp":1775333805083,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Shanghai Municipal Office of the Development of Chinese Medicine kyorin Nova Program","award":["ZYSNXD001-RC-XLXX-20130053"],"award-info":[{"award-number":["ZYSNXD001-RC-XLXX-20130053"]}]},{"name":"Shanghai Municipal TCM Scientific Research Fund Project","award":["2014LP024A"],"award-info":[{"award-number":["2014LP024A"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate the efficacy of Chinese herb Cistanche Yishen granules (CYG) in the treatment of tinnitus for patients with chronic nephritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 89 adult patients were diagnosed with chronic glomerulonephritis from January 2016 to December 2017. All the patients were randomly divided into two groups, such as the control group and the CYG group. The efficacy of tinnitus was determined using tinnitus handicap inventory (THI), Pittsburgh sleep quality index (PSQI), pure tone audiometry (PTA), speech reception threshold (SRT), and visual analog scale (VAS) for tinnitus loudness and annoyance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In both these two groups of patients, values of THI, PSQI, PTA, SRT, and VAS for tinnitus loudness and annoyance were significantly decreased after the treatment compared with those before treatment. However, all values in CYG group after the treatment were significantly lower than those in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CYG could apparently release the tinnitus symptoms in the patients with chronic nephritis. This study might give more clinical evidence for Cistanche in the treatment of tinnitus and give a new treatment method for the patients with tinnitus.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.27833","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T10:04:59Z","timestamp":1543226699000},"page":"5505-5509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of Chinese herb Cistanche Yishen granules in treatment of tinnitus for patients with chronic nephritis"],"prefix":"10.1002","volume":"120","author":[{"given":"Xiaoli","family":"Fan","sequence":"first","affiliation":[{"name":"The First School of Clinical Medicine, Nanjing University of Chinese Medicine Nanjing China"},{"name":"Department of T\u00c7M Tongren Hospital Shanghai, Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of T\u00c7M Tongren Hospital Shanghai, Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of T\u00c7M Tongren Hospital Shanghai, Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of T\u00c7M Tongren Hospital Shanghai, Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of T\u00c7M Tongren Hospital Shanghai, Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of T\u00c7M Tongren Hospital Shanghai, Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danyang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of T\u00c7M Tongren Hospital Shanghai, Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9901-1361","authenticated-orcid":false,"given":"Meixiao","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Nephrology Jiangsu Province Hospital of TCM, Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,26]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60142-7"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3283577b81"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.02.015"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2016.05.009"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2013.08.002"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21426"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70160-1"},{"key":"e_1_2_8_1_9_1","first-page":"4","article-title":"The pathogenesis of liver and kidney of tinnitus, deafness is analysed from the heart","author":"Wang M","year":"2016","journal-title":"Chinese Journal of Ethnomedicine & Ethnopharmacy"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183192"},{"key":"e_1_2_8_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2013.02.005"},{"key":"e_1_2_8_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(07)66023-3"},{"key":"e_1_2_8_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2927"},{"key":"e_1_2_8_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2010.01.047"},{"key":"e_1_2_8_1_15_1","first-page":"557","article-title":"Effects of Cistanche deserticola extract on penis erectile response in castrated rats","volume":"29","author":"Gu L","year":"2016","journal-title":"Pak J Pharm Sci"},{"key":"e_1_2_8_1_16_1","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification","volume":"39","author":"Foundation NK","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"e_1_2_8_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2015.01.002"},{"key":"e_1_2_8_1_18_1","first-page":"37","article-title":"Health and nutrition examination survey of 1971\u201075: Part II. 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