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Metastasis\u2010associated lung adenocarcinoma transcript 1 (MALAT\u20101) has been associated with gene regulation and alternative splicing. It has shown relationship with proliferation, apoptosis, migration, and invasion. In this study, we found that MALAT\u20101 expression was downregulated in MG. The level of the miR\u2010338\u20103p was increased in peripheral blood mononuclear cells from MG patients compared with those from control subjects. MALAT\u20101 competed for binding to miR\u2010338\u20103p with male\u2010specific lethal 2 (MSL2) in luciferase reporter assays. We confirmed the MALAT\u20101\u2010miR\u2010338\u20103p\u2010MSL2 interaction network in MG in vitro. 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