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This compound also decreases the levels of TNF\u2010\u03b1, IL\u20106, and IL\u20101\u03b2 in intestinal tissue of mice with experimental colitis in a concentration\u2010dependent manner. \u03b2\u2010Sitosterol treatment to intestinal epithelial cells significantly increases expression of antimicrobial peptides and reduces survival of intracellular <jats:italic>Salmonella typhimurium<\/jats:italic>. These results showed the multiple effects of \u03b2\u2010sitosterol against pathogenic bacteria for a novel approach to the treatment of colonic inflammation.<\/jats:p>","DOI":"10.1002\/jcb.27853","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T06:41:45Z","timestamp":1544596905000},"page":"5687-5694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["\u03b2\u2010Sitosterol improves experimental colitis in mice with a target against pathogenic bacteria"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3628-7448","authenticated-orcid":false,"given":"Kang","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery The Third Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing Jiangsu 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