{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T02:56:53Z","timestamp":1769050613204,"version":"3.49.0"},"reference-count":69,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T00:00:00Z","timestamp":1541116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Liuzhou Administration of Science and Technology, Guangxi, China","award":["2014G020403"],"award-info":[{"award-number":["2014G020403"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Currently, studies have shown that microRNA\u201093 (miR\u201093) can be an oncogene or a tumor suppressor in different kinds of cancers. The role of miR\u201093 in human cancers is inconsistent and the underlying mechanism on the aberrant expression of miR\u201093 is complicated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We first conducted gene enrichment analysis to give insight into the prospective mechanism of miR\u201093. Second, we performed a meta\u2010analysis to evaluate the clinical value of miR\u201093. Finally, a validation test based on quantitative polymerase chain reaction (qPCR) was performed to further investigate the role of miR\u201093 in pan\u2010cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gene Ontology (GO) enrichment analysis results showed that the target genes of miR\u201093 were closely related to transcription, and MAPK1, RBBP7 and Smad7 became the hub genes. In the diagnostic meta\u2010analysis, the overall sensitivity, specificity, and area under the curve were 0.76 (0.64\u20100.85), 0.82 (0.64\u20100.92), and 0.85 (0.82\u20100.88), respectively, which suggested that miR\u201093 had excellent performance on the diagnosis for human cancers. In the prognostic meta\u2010analysis, dysregulated miR\u201093 was found to be associated with poor OS in cancer patients. In the qPCR validation test, the serum levels of miR\u201093 were upregulated in breast cancer, breast hyperplasia, lung cancer, chronic obstructive pulmonary disease, nasopharyngeal cancer, hepatocellular cancer, gastric ulcer, endometrial cancer, esophageal cancer, laryngeal cancer, and prostate cancer compared with healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>miR\u201093 could act as an effective diagnostic and prognostic factor for cancer patients. Its clinical value for cancer early diagnosis and survival prediction is promising.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.27924","type":"journal-article","created":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T04:05:42Z","timestamp":1541217942000},"page":"6370-6383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Molecular mechanism and role of microRNA\u201093 in human cancers: A study based on bioinformatics analysis, meta\u2010analysis, and quantitative polymerase chain reaction validation"],"prefix":"10.1002","volume":"120","author":[{"given":"Yun","family":"Gao","sequence":"first","affiliation":[{"name":"Medical Science Laboratory, The Fourth Affiliated Hospital of Guangxi Medical University Liuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaifeng","family":"Deng","sequence":"additional","affiliation":[{"name":"Medical Science Laboratory, The Fourth Affiliated Hospital 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