{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T09:08:55Z","timestamp":1788944935107,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,11]],"date-time":"2018-11-11T00:00:00Z","timestamp":1541894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,11,11]],"date-time":"2018-11-11T00:00:00Z","timestamp":1541894400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["EMR\/2016\/001849"],"award-info":[{"award-number":["EMR\/2016\/001849"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    infection is a healthcare problem to mankind for a considerable period of time. Once when it enters the bloodstream of an individual, it may potentially result in life\u2010threatening conditions. The resistance of\n                    <jats:italic>S. aureus<\/jats:italic>\n                    to various drugs such as penicillin, methicillin, gentamicin, erythromycin, and tetracycline have been well documented. Presently vancomycin is the drug of choice for methicillin resistant\n                    <jats:italic>S. aureus<\/jats:italic>\n                    . Scientists believe that\n                    <jats:italic>S. aureus<\/jats:italic>\n                    would completely develop resistance to vancomycin as well. Therefore there is a commensurate need to develop a drug to replace vancomycin. In the current study, we have focussed on FtsA, an important and vital cell division protein, which is found only in\n                    <jats:italic>S. aureus<\/jats:italic>\n                    and in other prokaryotic cells. We have carried out virtual screening process for FtsA against ZINC database, the best hit molecules obtained from the preliminary docking studies were subjected to SYBYL X 2.0 docking. The molecules ZINC74432848, ZINC37769607, and ZINC96896268 displayed the highest C\u2010score value of 4.89, 4.49, and 4.22, respectively. The top ranked molecule ZINC74432848 was observed to form 4 hydrogen bonds with FtsA. The simulation study reveals the greater stability of the FtsA\u2010ZINC74432848 complex. If the in vitro and in vivo study turns out affirmative, then ZINC74432848 could be developed as a potent drug for FtsA.\n                  <\/jats:p>","DOI":"10.1002\/jcb.28049","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T01:16:16Z","timestamp":1541985376000},"page":"7751-7758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["FtsA as a cidal target for\n                    <i>Staphylococcus aureus<\/i>\n                    : Molecular docking and dynamics studies"],"prefix":"10.1002","volume":"120","author":[{"given":"Adhithya","family":"Ragunathan","sequence":"first","affiliation":[{"name":"Department of Biotechnology Medical &amp; Biological Computing Laboratory, School of Biosciences and Technology, Vellore Institute of Technology Vellore Tamil Nadu 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