{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T09:08:56Z","timestamp":1788944936596,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T00:00:00Z","timestamp":1542585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T00:00:00Z","timestamp":1542585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dexmedetomidine (Dex) was reported to reduce ischemia\u2010reperfusion (I\/R) injury in kidney and brain tissues. Thus, we aimed to study the role and mechanism of Dex in cerebral I\/R injury by inhibiting hypoxia\u2010inducible factor\u20101\u03b1 (HIF\u20101\u03b1) and apoptosis. First, I\/R injury models were established. Six groups were assigned after different treatments: sham, I\/R, I\/R+Dex, I\/R+2\u2010methoxyestradiol (2ME2) (HIF\u20101\u03b1 inhibitor), I\/R+CoCl\n                    <jats:sub>2<\/jats:sub>\n                    (HIF\u20101\u03b1 activator), and I\/R+Dex+CoCl\n                    <jats:sub>2<\/jats:sub>\n                    groups. Neurological function, cerebral infarction volume, survival, and apoptosis of brain cells were then analyzed. Besides, immunohistochemistry and Western blot analysis were used to detect the expression of HIF\u20101\u03b1, BCL\u20102[B\u2010cell leukemia\/lymphoma 2] adenovirus E1B interacting protein 3 (BNIP3), B\u2010cell leukemia\/lymphoma 2 (BCL2), BCL2[B\u2010cell leukemia\/lymphoma 2] associated X (Bax), and cleaved\u2010caspase3 proteins in brain tissues. I\/R rats showed cerebral infarction, increased neurological function score, number of terminal\u2010deoxynucleoitidyl transferase mediated nick end labeling (TUNEL)\u2010positive cells and HIF\u20101\u03b1\u2013positive cells as well as decreased neurons. Inhibition of HIF\u20101\u03b1 can reduce the apoptosis induced by I\/R, and overexpression of HIF\u20101\u03b1 can aggravate apoptosis in brain tissue of I\/R rats. Furthermore, activation of HIF\u20101\u03b1 expression blocks the inhibitory effect of Dex on neuronal apoptosis in I\/R rats. Dex may inhibit the neuronal apoptosis of I\/R rats by inhibiting the HIF\u20101\u03b1 pathway and then improve the cerebral I\/R injury in rats.\n                  <\/jats:p>","DOI":"10.1002\/jcb.28058","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T23:40:59Z","timestamp":1542670859000},"page":"7834-7844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Dexmedetomidine\n                    <b>alleviates cerebral ischemia\u2010reperfusion injury in rats via inhibition of hypoxia\u2010inducible factor\u20101\u03b1<\/b>"],"prefix":"10.1002","volume":"120","author":[{"given":"Yuan\u2010Qing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology Rizhao People\u2019s Hospital Rizhao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Feng","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of 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