{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:17:11Z","timestamp":1740104231992,"version":"3.37.3"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400350"],"award-info":[{"award-number":["81400350"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Newcastle disease virus (NDV) is endowed with the oncolytic ability to kill tumor cells, while rarely causing side effects in normal cells. Both estrogen receptor \u03b1 (ER\u03b1) and the G protein estrogen receptor (GPER) modulate multiple biological activities in response to estrogen, including apoptosis in breast cancer (BC) cells. Here, we investigated whether NDV\u2010D90, a novel strain isolated from natural sources in China, promoted apoptosis by modulating the expression of ER\u03b1 or the GPER in BC cells exposed to 17\u03b2\u2010estradiol (E2). We found that NDV\u2010D90 significantly killed the tumor cell lines MCF\u20107 and BT549 in a time\u2010 and dose\u2010dependent manner. We also found that NDV\u2010D90 exerted its effects on the two cell lines mainly by inducing apoptosis but not necrosis. NDV\u2010D90 induced apoptosis via the intrinsic and extrinsic signaling pathways in MCF\u20107 cells (ER\u2010positive cells) during E2 exposure not only by disrupting the E2\/ER\u03b1 axis and enhancing GPER expression but also by modulating the expression of several apoptosis\u2010related proteins through ER\u03b1\u2010and GPER\u2010independent processes. NDV\u2010D90 promoted apoptosis via the intrinsic signaling pathway in BT549 cells (ER\u2010negative cells), possibly by impairing E2\u2010mediated GPER expression. Furthermore, NDV\u2010D90 exerted its antitumor effects in vivo by inducing apoptosis. Overall, these results demonstrated that NDV\u2010D90 promotes apoptosis by differentially modulating the expression of ER\u03b1 and the GPER in ER\u2010positive and negative BC cells exposed to estrogen, respectively, and can be utilized as an effective approach to treating BC.<\/jats:p>","DOI":"10.1002\/jcb.28118","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T15:37:24Z","timestamp":1601307444000},"page":"3-15","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["NDV\u2010D90 inhibits 17\u03b2\u2010estradiol\u2010mediated resistance to apoptosis by differentially modulating classic and nonclassic estrogen receptors in breast cancer cells"],"prefix":"10.1002","volume":"122","author":[{"given":"Peng","family":"Shan","sequence":"first","affiliation":[{"name":"Department of General Surgery, The Hepatosplenic Surgery Center The First Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Hepatosplenic Surgery Center The First Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Thyroid Gland and Breast Surgery The Affiliated Hospital of Hubei University of Traditional Chinese Medicine  Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Central Hospital of Pukou District  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiehou","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery The Second People's Hospital of Dezhou  Dezhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8896-3906","authenticated-orcid":false,"given":"Zheng","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Hepatosplenic Surgery Center The First Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Song","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Cell Transplantation of Ministry of Health and Department of General Surgery The First Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,28]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"International Agency for Research on Cancer(2013).International Agency for Research on Cancer. 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