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In this study, we investigated the association of <jats:italic>AhRR<\/jats:italic>\u2010c.565C&gt;G transversion polymorphism with male infertility. In a hospital\u2010based case\u2010control study, 221 semen samples (111 infertile and 110 healthy controls) based on\u00a0World Health Organization guidelines were collected from in vitro fertilization centers of Babol, Iran. The <jats:italic>AhRR<\/jats:italic>\u2010c.565C&gt;G (rs2292596) polymorphism was genotyped using a polymerase chain reaction\u2010restriction fragment length polymorphism analysis. The difference in the allele frequency of <jats:italic>AhRR<\/jats:italic>\u2010c.565C&gt;G transversion polymorphism did not reach a significant level. The genotype frequency was statistically significantly different between fertile and infertile men. We found that polymorphism rs2292596 (Pro185Ala) was statistically <jats:bold>s<\/jats:bold>ignificantly associated with the risk of male infertility. In addition, the statistical difference became more significant when the frequency was compared between the Pro\/Pro genotype and the Pro\/Ala plus Ala\/Ala genotype. The 185 Pro wild\u2010type alleles of <jats:italic>AhRR<\/jats:italic> may be associated with the risk of male infertility. The proallele also may diminish inhibition of AhR\u2010mediated signaling of exposure to environmental pollutants.<\/jats:p>","DOI":"10.1002\/jcb.28171","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T04:24:49Z","timestamp":1543811089000},"page":"8999-9005","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of the human aryl hydrocarbon receptor repressor (<i>AhRR<\/i>)\u2010c.565C&gt;G transversion with male infertility: A case\u2010control study from Iran"],"prefix":"10.1002","volume":"120","author":[{"given":"Azadeh","family":"Mohammad\u2010Hasani","sequence":"first","affiliation":[{"name":"Department of Molecular and Cell Biology Faculty of Basic Sciences, University of Mazandaran Babolsar 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