{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:24:20Z","timestamp":1787063060132,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,9]],"date-time":"2018-12-09T00:00:00Z","timestamp":1544313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chongqing Municipal Health Planning Commission Key Project","award":["20141006"],"award-info":[{"award-number":["20141006"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fetal growth restriction (FGR) is a serious pregnancy complication associated with increased perinatal mortality and morbidity. It may lead to neurodevelopmental impairment and adulthood onset disorders. Recently, long noncoding RNAs (lncRNAs) were found to be associated with the pathogenesis of FGR. Here we report that the lncRNAH19 is significantly decreased in placentae from pregnancies with FGR. Downregulation of H19 leads to reduced proliferation and invasion of extravillous trophoblast cells. This is identified with reduced trophoblast invasion, which has been discovered in FGR. Autophagy is exaggerated in FGR. Downregulation of H19 promotes autophagy via the PI3K\/AKT\/mTOR and MAPK\/ERK\/mTOR pathways of extravillous trophoblast cells in FGR. We also found that the expression level of microRNAs miR\u201018a\u20105p was negatively correlated with that of H19. H19 can act as an endogenous sponge by directly binding to miR\u201018a\u20105p, which targets IRF2. The expression of miR\u201018a\u20105p was upregulated, but IRF2 expression was downregulated after the H19 knockdown. In conclusion, our study revealed that H19 downexpressed could inhibit proliferation and invasion, and promote autophagy by targeting miR\u201018a\u20105pin HTR8 and JEG3 cells. We propose that aberrant regulation of H19\/miR\u201018a\u20105p\u2010mediated regulatory pathway may contribute to the molecular mechanism of FGR. We indicated that H19 may be a potential predictive, diagnostic, and therapeutic modality for FGR.<\/jats:p>","DOI":"10.1002\/jcb.28172","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T01:00:41Z","timestamp":1544403641000},"page":"9006-9015","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Silencing H19 regulated proliferation, invasion, and autophagy in the placenta by targeting miR\u201018a\u20105p"],"prefix":"10.1002","volume":"120","author":[{"given":"Lei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The Second Affiliated Hospital, Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Second Affiliated Hospital, Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Second Affiliated Hospital, Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0358-0042","authenticated-orcid":false,"given":"Xiaojing","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Second Affiliated Hospital, Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,9]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000429658.85846.f9"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.211185"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2017.01.004"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.486"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7270"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M504033200"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1913"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.01.033"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.4418"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.04.005"},{"key":"e_1_2_6_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2936"},{"key":"e_1_2_6_1_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers5020462"},{"key":"e_1_2_6_1_14_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.20481"},{"key":"e_1_2_6_1_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt182"},{"key":"e_1_2_6_1_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053823"},{"key":"e_1_2_6_1_17_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9534"},{"key":"e_1_2_6_1_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6073167"},{"key":"e_1_2_6_1_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2013.00248"},{"issue":"2","key":"e_1_2_6_1_20_1","first-page":"517","article-title":"Altered expression of mTOR and autophagy in term normal human placentas","volume":"58","author":"Zhang QX","year":"2017","journal-title":"Rom J Morphol Embryol"},{"key":"e_1_2_6_1_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.733764"},{"key":"e_1_2_6_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2017.117"},{"key":"e_1_2_6_1_23_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.031773"},{"key":"e_1_2_6_1_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040957"},{"key":"e_1_2_6_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2017.12.051"},{"issue":"7","key":"e_1_2_6_1_26_1","first-page":"3474","article-title":"IncRNA H19 promotes tongue squamous cell carcinoma progression through \u03b2\u2010catenin\/GSK3\u03b2\/EMT signaling via association with EZH2","volume":"9","author":"Zhang DM","year":"2017","journal-title":"Am J Transl Res"},{"key":"e_1_2_6_1_27_1","doi-asserted-by":"publisher","DOI":"10.5603\/FHC.2012.0026"},{"key":"e_1_2_6_1_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.055277"},{"key":"e_1_2_6_1_29_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.039511"},{"key":"e_1_2_6_1_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140918319"},{"key":"e_1_2_6_1_31_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.20807"},{"key":"e_1_2_6_1_32_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S149908"},{"key":"e_1_2_6_1_33_1","doi-asserted-by":"publisher","DOI":"10.3727\/096504018X15178768577951"},{"key":"e_1_2_6_1_34_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.24273"},{"key":"e_1_2_6_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.12.018"},{"key":"e_1_2_6_1_36_1","doi-asserted-by":"publisher","DOI":"10.2741\/4471"},{"key":"e_1_2_6_1_37_1","doi-asserted-by":"publisher","DOI":"10.1042\/bse0550105"},{"key":"e_1_2_6_1_38_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2016.0530"},{"key":"e_1_2_6_1_39_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201593596"},{"key":"e_1_2_6_1_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2017.1339845"},{"key":"e_1_2_6_1_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-016-0351-x"},{"key":"e_1_2_6_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2018.07.013"},{"key":"e_1_2_6_1_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.163"},{"key":"e_1_2_6_1_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-13-78"},{"key":"e_1_2_6_1_45_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI73939"},{"key":"e_1_2_6_1_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.002353"},{"key":"e_1_2_6_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.02.011"},{"key":"e_1_2_6_1_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-014-0991-2"},{"key":"e_1_2_6_1_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12327"},{"key":"e_1_2_6_1_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/02699050500284218"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.28172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.28172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcb.28172","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.28172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T03:43:30Z","timestamp":1714707810000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.28172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,9]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/jcb.28172"],"URL":"https:\/\/doi.org\/10.1002\/jcb.28172","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,9]]},"assertion":[{"value":"2018-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}