{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:37:44Z","timestamp":1774330664832,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,23]],"date-time":"2018-12-23T00:00:00Z","timestamp":1545523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Interstitial cystitis (IC) is a heterogeneous syndrome with unknown etiology, and microRNAs (miRs) were found to be involved in IC. In our study, we aim to explore the role of miR\u2010132 in the inflammatory response and detrusor fibrosis in IC through the Janus kinase\u2010signal transducer and activator of transcription (JAK\u2010STAT) signaling pathway in rat models. A rat model of IC was established and treated with the miR\u2010132 mimic, miR\u2010132 inhibitor, and\/or JAK\u2010STAT signaling pathway inhibitor AG490. Enzyme\u2010linked immunosorbent assay was applied to measure the expression of interleukin (IL)\u20106, IL\u201010, interferon\u2010\u03b3 (IFN\u2010\u03b3), and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), and intercellular adhesion molecule\u20101 (ICAM\u20101). The urodynamic test was performed to assess urodynamic parameters, and reverse transcription quantitative polymerase chain reaction and Western blot analysis for the expression of miR\u2010132, STAT4, suppressors of cytokine signaling 3 (SOCS3), JAK2, vascular endothelial growth factor (VEGF), IFN\u2010\u03b3, and TNF\u2010\u03b1. IC rats treated with miR\u2010132 inhibitor and AG490 had decreased collagen fiber, inflammatory cell infiltration, and mast cells, lower expression of IL\u20106, IL\u201010, IFN\u2010\u03b3, TNF\u2010\u03b1, ICAM\u20101, collagens I and III, and alleviated urodynamic parameters and decreased expression of STAT4, VEGF, JAK2, IFN\u2010\u03b3, TNF\u2010\u03b1, and increased expression of SOCS3. Taken together, our data indicate that downregulation of miR\u2010132 alleviates inflammatory response and detrusor fibrosis in IC via the inhibition of the JAK\u2010STAT signaling pathway.<\/jats:p>","DOI":"10.1002\/jcb.28190","type":"journal-article","created":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T07:25:05Z","timestamp":1545636305000},"page":"9147-9158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Inhibition of microRNA\u2010132 attenuates inflammatory response and detrusor fibrosis in rats with interstitial cystitis via the JAK\u2010STAT signaling pathway"],"prefix":"10.1002","volume":"120","author":[{"given":"Ya\u2010Jun","family":"Song","sequence":"first","affiliation":[{"name":"Department of Urology Xinqiao Hospital, Third Military Medical University Chongqing P. R. 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