{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T05:59:04Z","timestamp":1759730344315,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T00:00:00Z","timestamp":1544140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/11371\u20105","2018\/08481\u20101"],"award-info":[{"award-number":["2015\/11371\u20105","2018\/08481\u20101"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The process of combating neoplasms and mononuclear cells, and during <jats:italic>H. pylori<\/jats:italic> infection, several pro\u2010inflammatory and anti\u2010inflammatory cytokines are synthesized. In view of the involvement of the IL\u20106 law and the presence of <jats:italic>H. pylori<\/jats:italic> in the development of gastric diseases, the present study aimed to characterize the promoter\u2010region polymorphism \u2212597 (G\/A) (rs1800797), \u2212572 (C\/G) (rs1800796), and \u2212174 (G\/C) (rs1800795) by PCR\u2010RFLP in 375 gastric biopsy specimens from patients with peptic symptoms. A total of 375 samples were analyzed: 87 patients (without lesion without gastric tissue); 236 patients with gastritis and 52 patients with gastric cancer analyzed the PCR\u2010RFLP techniques. All the results were normalized in relation to the presence of <jats:italic>H. pylori<\/jats:italic>. The frequencies of the three polymorphisms were compared in the Control vs Gastritis groups and a statistically significant test observed: \u2212174 (G\/C) (OR: 1.27; 95% CI: 0.84\u20131.93; <jats:italic>P<\/jats:italic>\u2009=\u20090.26), 572 (C\/G) (OR: 1.42; 95% CI: 0.78\u20132.59; <jats:italic>P<\/jats:italic>\u2009=\u20090.25), and 597 (G\/A) (OR: 0.98; 95% CI, 0.64\u20131.52; <jats:italic>P<\/jats:italic>\u2009=\u20090.94). Similar results were obtained when the gastric cancer group was compared to the control group: \u2212174 (G\/C) (OR: 1.27; 95% CI: 0.66\u20132.47; <jats:italic>P<\/jats:italic>\u2009=\u20090.47), \u2212572 (C\/G) (OR: 1.07; 95% CI: 0.43\u20132.68; <jats:italic>P<\/jats:italic>\u2009=\u20090.88), and \u2212597 (G\/A) (OR: 1.01; 95% CI, 0.5\u20130.9; <jats:italic>P<\/jats:italic>\u2009=\u20090.99). The haplotypes were and were not observed statistically significant differences. In conclusion, we found no correlations between any of the three polymorphisms in the IL\u20106 gene analyzed in this study and a higher risk of gastritis or gastric cancer.<\/jats:p>","DOI":"10.1002\/jcb.28220","type":"journal-article","created":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T13:50:48Z","timestamp":1544190648000},"page":"9448-9454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Lack of Association between IL\u20106 Polymorphisms and Haplotypes with Gastric Cancer"],"prefix":"10.1002","volume":"120","author":[{"given":"M\u00f4nica Pezenatto","family":"dos Santos","sequence":"first","affiliation":[{"name":"Universidade do Sagrado Cora\u00e7\u00e3o (USC)  Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayara Luciana","family":"Sallas","sequence":"additional","affiliation":[{"name":"Universidade do Sagrado Cora\u00e7\u00e3o (USC)  Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Zapparoli","sequence":"additional","affiliation":[{"name":"Universidade do Sagrado Cora\u00e7\u00e3o (USC)  Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilson Aparecido","family":"Orcini","sequence":"additional","affiliation":[{"name":"Universidade do Sagrado Cora\u00e7\u00e3o (USC)  Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Chen","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, (UNIFESP)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilia de Arruda Cardoso","family":"Smith","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, (UNIFESP)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spencer L. Marques","family":"Pay\u00e3o","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Marilia (FAMEMA) \u2010 Hemocentro  Mar\u00edlia S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9033-2257","authenticated-orcid":false,"given":"Lucas Trevizani","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Universidade do Sagrado Cora\u00e7\u00e3o (USC)  Bauru S\u00e3o Paulo Brazil"},{"name":"Faculdade de Medicina de Marilia (FAMEMA) \u2010 Hemocentro  Mar\u00edlia S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,7]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.4238\/2015.December.14.20"},{"issue":"2","key":"e_1_2_8_1_3_1","first-page":"6","article-title":"gabay 2006","volume":"8","author":"Gabay C","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2015.1093722"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2016.0156"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-199708000-00008"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2016.08.010"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2014.01.001"},{"key":"e_1_2_8_1_9_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297916020024"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277\u2010016\u20105098\u20107"},{"key":"e_1_2_8_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mgene.2015.03.002"},{"key":"e_1_2_8_1_12_1","unstructured":"DoutoraP CarvalhoL &SampaioDP(2012). 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