{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T10:43:15Z","timestamp":1764240195810,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600020"],"award-info":[{"award-number":["81600020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2016GXNSFBA380100"],"award-info":[{"award-number":["2016GXNSFBA380100"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The elevated S100A4 level has been found in some inflammatory diseases. However, the expression and role of S100A4 in asthma is unknown. The expression of S100A4 in induced sputum and plasma from healthy control and asthmatics were assessed by ELISA. Then an allergen\u2010induced asthma mouse model treatment with anti\u2010S100A4 antibody was used to explore the role of S100A4 in the pathogenesis of asthma. The S100A4 levels in sputum not in plasma in asthmatics were significantly increased than those of healthy controls and were negatively correlated with some lung function parameters and were positively correlated with sputum eosinophilia and lymphocyte. The expression of S100A4 in the lung as well as in BALF were also significantly higher in the asthma mouse model and treatment with anti\u2010S100A4 antibody exhibited reductions in inflammatory cell accumulation, inflammatory mediators, and airway hyper\u2010responsiveness. We further showed that LY294002, a specific inhibitor of PI3K, markedly decreased S100A4 expression in lung and S100A4 secretion in BALF in asthmatic mice. In conclusion, these data demonstrated that S100A4 may be involved in the pathogenesis of airway inflammation in asthma.<\/jats:p>","DOI":"10.1002\/jcb.28245","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T05:26:12Z","timestamp":1545283572000},"page":"9667-9676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Elevated S100A4 in asthmatics and an allergen\u2010induced mouse asthma model"],"prefix":"10.1002","volume":"120","author":[{"given":"Xiaolin","family":"Huang","sequence":"first","affiliation":[{"name":"The Department of Intensive Care Unit The Second Affiliated Hospital of Guangxi Medical University  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongming","family":"Qu","sequence":"additional","affiliation":[{"name":"The Department of Respiratory Medicine The Second Affiliated Hospital of Guangxi Medical University  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Liang","sequence":"additional","affiliation":[{"name":"The Department of Respiratory Medicine, The Eighth People's Hospital of Nanning City Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghua","family":"Huang","sequence":"additional","affiliation":[{"name":"The Department of Respiratory Medicine The Second Affiliated Hospital of Guangxi Medical University  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengze","family":"Li","sequence":"additional","affiliation":[{"name":"The Department of Respiratory Medicine The Second Affiliated Hospital of Guangxi Medical University  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6246-2241","authenticated-orcid":false,"given":"Changchun","family":"Hou","sequence":"additional","affiliation":[{"name":"The Department of Respiratory Medicine The Second Affiliated Hospital of Guangxi Medical University  China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,19]]},"reference":[{"key":"e_1_2_6_1_2_1","unstructured":"GINA. 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