{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:28:28Z","timestamp":1791523708675,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:00:00Z","timestamp":1543968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004924","name":"Guangxi Traditional Chinese Medical University","doi-asserted-by":"publisher","award":["2018002"],"award-info":[{"award-number":["2018002"]}],"id":[{"id":"10.13039\/501100004924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Astrocyte elevated gene\u20101 (AEG\u20101), also known as metadherin, 3D3, and lysine\u2010rich carcinoembryonic antigen\u2010related cell adhesion molecule 1 (CEACAM1) coisolated, has emerged as an important oncogene that is overexpressed in a variety of cancers. Previous studies revealed that AEG\u20101 is also involved in multiple physiological and pathological processes, such as development, inflammation, neurodegeneration, migraine, and Huntington's disease. However, the function of AEG\u20101 in diabetic cardiomyopathy (DCM) has not been reported yet. Therefore, we conducted this study to characterize the potential role and mechanism of AEG\u20101 in DCM rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>DCM was induced by injections of streptozocin (STZ) in Wistar rats. Rats were randomized to be injected with lentivirus carrying AEG\u20101 small interfering RNA. Haemodynamic changes of Wistar rats, assessment of cardiac weight index, and the expression of AEG\u20101 and KLF4 were detected and compared among these three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The expressions of AEG\u20101 and KLF4 in the STZ group were significantly elevated in cardiac tissues compared with the control group. Knockdown of AEG\u20101 significantly increased the values of left ventricular ejection fraction, \u00b1dp\/dt \n<jats:sub>max<\/jats:sub>, repressed autophagy, as well as upregulated the expression of KLF4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Knockdown of AEG\u20101 suppresses autophagy in DCM by downregulating the expression of KLF4. This study provide first\u2010notion evidence for the potential value of AEG\u20101 as a therapeutic target for the treatment of the patients with DCM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.28249","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T04:18:23Z","timestamp":1544069903000},"page":"9709-9715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Astrocyte elevated gene\u20101 induces autophagy in diabetic cardiomyopathy through upregulation of KLF4"],"prefix":"10.1002","volume":"120","author":[{"given":"Lichun","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Guangxi University of Chinese Medicine Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Guangxi University of Chinese Medicine Nanning 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