{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:59:55Z","timestamp":1778666395422,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T00:00:00Z","timestamp":1544486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006402","name":"Fasa University of Medical Sciences","doi-asserted-by":"publisher","award":["95124"],"award-info":[{"award-number":["95124"]}],"id":[{"id":"10.13039\/501100006402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Recently, it has been revealed that estrogen\u2010related reproductive factors are linked with some early gene expression lesions associated with malignancy in clinically healthy breasts. Accordingly, the aim of the current study was to evaluate the association of expression levels of estrogen\u2010related long noncoding RNAs (lncRNAs) upstream Eleanor (u\u2010Eleanor) and\n                    <jats:italic>HOX<\/jats:italic>\n                    antisense intergenic RNA (HOTAIR) with the different patterns of reproductive factors in breast tissue of healthy women. The subjects of this study were 98 cancer\u2010free women who had undergone cosmetic mammoplasty. The expression levels of u\u2010Eleanor and HOTAIR were measured using quantitative real\u2010time polymerase chain reaction. The results of the current study showed that the women without a history of breastfeeding had a high\u2010level expression of u\u2010Eleanor compared with the women with a breastfeeding duration greater than 6 to 24 months (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.03) as well as the women with a breastfeeding duration of more than 24 months (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.005). Furthermore, a higher expression of u\u2010Eleanor was found in the women with a short breastfeeding duration for 1 to 6 months than that in the women with a breastfeeding duration of greater than 24 months (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.02). In the same way, the results of correlation test (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u22120.258;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.036) and multivariate regression model (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.321;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.023) are indicative of a significant relationship of elevated expression of u\u2010Eleanor with decreasing breastfeeding duration in the women. These findings could be important to identify the molecular mechanisms behind the relationship between a lack or short duration of the breastfeeding and the risk of breast cancer, which has previously been reported by epidemiological studies.\n                  <\/jats:p>","DOI":"10.1002\/jcb.28269","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T01:43:31Z","timestamp":1544579011000},"page":"9869-9876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Breast cancer\u2010linked lncRNA u\u2010Eleanor is upregulated in breast of healthy women with lack or short duration of breastfeeding"],"prefix":"10.1002","volume":"120","author":[{"given":"Yaser","family":"Mansoori","sequence":"first","affiliation":[{"name":"Noncommunicable Diseases Research Center, Fasa University of Medical Sciences Fasa Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Zendehbad","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics School of Medicine, Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Askari","sequence":"additional","affiliation":[{"name":"Department of Orthopedy Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin","family":"Kouhpayeh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Fasa University of Medical Sciences Fasa Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1623-1463","authenticated-orcid":false,"given":"Javad","family":"Tavakkoly\u2010Bazzaz","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics School of Medicine, Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziba","family":"Nariman\u2010Saleh\u2010Fam","sequence":"additional","affiliation":[{"name":"Women's Reproductive Health Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milad","family":"Bastami","sequence":"additional","affiliation":[{"name":"Immunology Research Center, Stem Cell and Regenerative Medicine Institute Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Saadatian","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Faculty of Medicine, Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behnam","family":"Mansoori","sequence":"additional","affiliation":[{"name":"Noncommunicable Diseases Research Center, Fasa University of Medical Sciences Fasa Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin","family":"Yousefvand","sequence":"additional","affiliation":[{"name":"Department of Food Hygiene Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hosein","family":"Mansoori","sequence":"additional","affiliation":[{"name":"Noncommunicable Diseases Research Center, Fasa University of Medical Sciences Fasa Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2106-835X","authenticated-orcid":false,"given":"Abdolreza","family":"Daraei","sequence":"additional","affiliation":[{"name":"Department of Genetics Faculty of Medicine, Babol University of Medical Sciences Babol 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