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Type 1 diabetes mellitus (T1DM) was induced in 72 rats, divided into four groups,\u00a0harboring 18 rats each: group 1 served as a control group, group 2 received PBMT, group 3 received CM, and group 4 received CM\u2009+\u2009PBMT. On days 4, 7, and 15, six animals from each group were euthanized and the skin samples were separated for stereology examination and gene expression analysis by real\u2010time polymerase chain reaction. In the CM\u2009+\u2009PBMT, CM, and PBMT groups, significant decreases were induced in the number of neutrophils (1460\u2009\u00b1\u200993, 1854\u2009\u00b1\u2009138, 1719\u2009\u00b1\u2009248) and macrophages (539\u2009\u00b1\u200969, 804\u2009\u00b1\u200963, 912\u2009\u00b1\u200941), and significant increases in the number of fibroblasts (1073\u2009\u00b1\u2009116, 836\u2009\u00b1\u200975, 912\u2009\u00b1\u200941) and angiogenesis (15\u2009230\u2009\u00b1\u2009516, 13\u2009318\u2009\u00b1\u20091116, 14\u2009041\u2009\u00b1\u2009867), compared with those of the control group (2690\u2009\u00b1\u2009371, 1139\u2009\u00b1\u2009145, 566\u2009\u00b1\u200990, 12\u2009585\u2009\u00b1\u20091219). Interestingly, the findings of the stereological examination in the CM\u2009+\u2009PBMT group were statistically more significant than those\u00a0in the other groups. In the PBMT group, in most cases, the expression of <jats:italic>bFGF<\/jats:italic>, <jats:italic>HIF\u20101\u03b1<\/jats:italic>, and <jats:italic>SDF\u20101\u03b1<\/jats:italic>, on day 4 (27.7\u2009\u00b1\u20090.14, 28.8\u2009\u00b1\u20090.52, 27.5\u2009\u00b1\u20090.54) and day 7 (26.8\u2009\u00b1\u20091.4, 29.6\u2009\u00b1\u20091.4, 28.3\u2009\u00b1\u20091.2) were more significant than those\u00a0in the control (day 4, 19.3\u2009\u00b1\u20090.42, 25.5\u2009\u00b1\u20090.08, 22.6\u2009\u00b1\u20090.04; day 7, 22.3\u2009\u00b1\u20090.22, 28.3\u2009\u00b1\u20090.59, 24.3\u2009\u00b1\u20090.19) and other treatment groups. The application of PBMT + CM induced anti\u2010inflammatory and angiogenic activities, and hastened wound healing process in a T1 DM model of MRSA infected wound.<\/jats:p>","DOI":"10.1002\/jcb.28273","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T07:54:57Z","timestamp":1545033297000},"page":"9906-9916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Improvement in infected wound healing in type 1 diabetic rat by the synergistic effect of photobiomodulation therapy and conditioned medium"],"prefix":"10.1002","volume":"120","author":[{"given":"Mohammadjavad","family":"Fridoni","sequence":"first","affiliation":[{"name":"Department of Anatomical Sciences School of Medicine, Zanjan University of Medical Sciences and Price Institue Of Surgical Research, University of Louisville, Kentucky Zanjan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Kouhkheil","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences School of Medicine, Zanjan University of Medical Sciences and Price Institue Of Surgical Research, University of Louisville, Kentucky Zanjan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad\u2010Amin","family":"Abdollhifar","sequence":"additional","affiliation":[{"name":"Department of Biology and Anatomical Sciences Shahid Beheshti University of Medical Sciences (SBMU) Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdollah","family":"Amini","sequence":"additional","affiliation":[{"name":"Department of Biology and Anatomical Sciences Shahid Beheshti University of Medical Sciences (SBMU) Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdi","family":"Ghatrehsamani","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord  Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Kamran","family":"Ghoreishi","sequence":"additional","affiliation":[{"name":"Department of Statistics University of Qom Qom Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sufan","family":"Chien","sequence":"additional","affiliation":[{"name":"Price Institute of Surgical Research, University of Louisville, and Noveratech LLC of Louisville Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Bayat","sequence":"additional","affiliation":[{"name":"Atherton High School Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5214-4223","authenticated-orcid":false,"given":"Mohammad","family":"Bayat","sequence":"additional","affiliation":[{"name":"Department of Biology and Anatomical Sciences Shahid Beheshti University of Medical Sciences (SBMU) Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,16]]},"reference":[{"key":"e_1_2_8_1_2_1","unstructured":"2014 Centers for Disease Control and Prevention Washington DC Control CfD Prevention More than 29 million Americans have diabetes; 1 in 4 doesn't know. 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