{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T14:55:06Z","timestamp":1770994506596,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T00:00:00Z","timestamp":1544486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400225"],"award-info":[{"award-number":["81400225"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>MicroRNAs (miRNAs) have been shown to play crucial roles in the occurrence, development, and treatment of many cardiovascular diseases. Coronary heart disease (CAD)\u2010related miRNAs are still a growing research area. miR\u20107b was reported to be downregulated in acute myocardial infarction (AMI) myocardium tissues. However, it remains largely unknown whether miR\u20107b is involved in the pathogenesis and progression of the AMI ischemia\/reperfusion (I\/R) injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male C57BL\/6\u2009J mice and H9C2 cells were used as models in this study. Masson staining, real\u2010time polymerase chain reaction, Western blot analysis, and terminal deoxynucleotidyl transferase\u2010mediated dUTP nick\u2010end\u2010labeling immunofluorescence staining assays were performed to detect the related indicators in the study. SPSS 17.0 software was used to calculate the experimental data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed that miR\u20107b expression is downregulated after I\/R in mice, and miR\u20107b could inhibit apoptosis in I\/R\u2010induced H9C2 cells via upregulating hypoxia\u2010inducible factor 1a (HIF1a). The inhibitory effect of miR\u20107b on I\/R\u2010induced apoptosis in H9C2 cells was blocked by HIF1a silencing. In addition, our data suggested that the p\u2010P38 pathway may be involved in the role of miR\u20107 in I\/R\u2010induced H9C2 cell apoptosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We confirmed that the overexpression of miR\u20107b inhibits I\/R\u2010induced apoptosis in H9C2 cells by targeting the HIF1a\/p\u2010P38 pathway. Our findings not only demonstrate the potential role of miR\u20107b in attenuating I\/R\u2010induced apoptosis but also provide a new insight into the better prevention of the I\/R injury by mediating HIF\u20101 and p\u2010P38.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.28277","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T06:41:08Z","timestamp":1544596868000},"page":"9947-9955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["MicroRNA\u20107b attenuates ischemia\/reperfusion\u2010induced H9C2 cardiomyocyte apoptosis via the hypoxia inducible factor\u20101\/p\u2010p38 pathway"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4292-2428","authenticated-orcid":false,"given":"Zulong","family":"Sheng","sequence":"first","affiliation":[{"name":"Department of Cardiology Zhongda Hospital, Medical School of Southeast University Nanjing 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