{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T21:04:19Z","timestamp":1772485459375,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T00:00:00Z","timestamp":1544486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Reseach Council of University of Tehran","award":["12345"],"award-info":[{"award-number":["12345"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tyrosine kinase inhibitor (TKI)\u2010based therapy has created promising results among much chronic myeloid leukemia (CML) patients. Imatinib as a relatively specific inhibitor of Bcr\u2010Abl is at present one of the undisputed therapeutic agent for newlydiagnosed patients with CML. However, the occurrence of imatinib\u2010resistance enlightens the urgent need to identify other therapeutic agents against CML. Juglone (5\u2010hydroxy\u20102\u2010methyl\u20101, 4\u2010naphthoquinone) exerts cytotoxic effects against various human cancer cell lines. However, the mechanisms through which Juglone induces anticancer effects in CML especially in comparison with imatinib treatment remain unknown. Our results revealed that Juglone\u2010inhibited K562 cells growth through inducing apoptosis. Based on our Western blot analyses, Juglone significantly reduced p\u2010Akt levels and increased the expression level of Forkhead box O1 (FoxO1) and FoxO3a proteins. Moreover, hairy\/enhancer of split\u20101 (Hes1) protein, overexpressed under the influence of Juglone, is apparently involved in Juglone\u2010induced apoptosis among K562 cells. Conversely, treatment with imatinib attenuated Hes1 protein expression. Considering the different functional mechanism of Juglone compared with imatinib, it seems that Juglone treatment could be a useful alternative strategy for the treatment of patients with imatinib\u2010resistance.<\/jats:p>","DOI":"10.1002\/jcb.28296","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T06:39:37Z","timestamp":1544596777000},"page":"10128-10136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Overexpression of Hes1 is involved in sensitization of K562 cells to Imatinib"],"prefix":"10.1002","volume":"120","author":[{"given":"Sedigheh","family":"Eskandari","sequence":"first","affiliation":[{"name":"Institute of Biochemistry and Biophysics, University of Tehran Tehran 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