{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:33:42Z","timestamp":1789065222858,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T00:00:00Z","timestamp":1547164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Finding ways to reduce myocardial ischemia\/reperfusion injury in the process of myocardial infarction has been an area of intense study in the field of heart disease. Recent studies have shown that long noncoding RNA (lncRNA) and autophagy play important roles in cardiovascular diseases. In our study, software analysis and dual\u2010luciferase reporter assays have shown that miR\u201030a has binding sites on both AK088388 and Beclin\u20101. Continuing experiments found that miR\u201030a expression is downregulated, while the expressions of AK088388, Beclin\u20101, and LC3\u2010II are upregulated in hypoxia\/reoxygenation (H\/R) cardiomyocytes; miR\u201030a inhibits the expression of AK088388, Beclin\u20101, and LC3\u2010II in H\/R cardiomyocytes, while AK088388 promotes the expression of Beclin\u20101 and LC3\u2010II and inhibits miR\u201030a expression. AK088388 small interfering RNA and miR\u201030a mimics can promote the viability of H\/R cardiomyocytes, reduce lactate dehydrogenase release, and reduce apoptosis. Mutations of the miR\u201030a binding site in AK088388 could not block the effects of miR\u201030a mentioned above. Therefore, AK088388 can competitively bind to miR\u201030a, promoting the expression of Beclin\u20101 and LC3\u2010II, autophagy, and eventually cell damage. This finding provides new evidence for understanding the role of lncRNA in myocardial ischemia\/reperfusion injury.<\/jats:p>","DOI":"10.1002\/jcb.28300","type":"journal-article","created":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T07:28:51Z","timestamp":1547278131000},"page":"10155-10163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Long noncoding RNA AK088388 regulates autophagy through miR\u201030a to affect cardiomyocyte injury"],"prefix":"10.1002","volume":"120","author":[{"given":"Jing\u2010jing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medicine Xi\u2019an Jiaotong University Xi\u2019an Shanxi China"},{"name":"Department of Cardiology General Hospital of Ningxia Medical University Yinchuan Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010dong","family":"Bie","sequence":"additional","affiliation":[{"name":"Department of Cardiology Yantai Yuhuangding Hospital Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1579-1090","authenticated-orcid":false,"given":"Chao\u2010feng","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,11]]},"reference":[{"key":"e_1_2_5_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1606915"},{"key":"e_1_2_5_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.207"},{"key":"e_1_2_5_1_4_1","article-title":"Opportunities for microRNAs in the crowded field of cardiovascular biomarkers","author":"Halushka PV","year":"2018","journal-title":"Annu Rev Pathol"},{"key":"e_1_2_5_1_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000795"},{"key":"e_1_2_5_1_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050926"},{"key":"e_1_2_5_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2013.04.001"},{"key":"e_1_2_5_1_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1106"},{"key":"e_1_2_5_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-009-0070-1"},{"key":"e_1_2_5_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2014.04.016"},{"key":"e_1_2_5_1_11_1","first-page":"345605","article-title":"An integrated analysis of miRNA, lncRNA, and mRNA expression profiles","volume":"2014","author":"Guo L","year":"2014","journal-title":"BioMed Res Int"},{"key":"e_1_2_5_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12243"},{"key":"e_1_2_5_1_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.5909"},{"key":"e_1_2_5_1_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.889048"},{"key":"e_1_2_5_1_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1275-x"},{"key":"e_1_2_5_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.07.010"},{"key":"e_1_2_5_1_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053950"},{"key":"e_1_2_5_1_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080817"},{"key":"e_1_2_5_1_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.302476"},{"key":"e_1_2_5_1_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000261924.76669.36"},{"key":"e_1_2_5_1_21_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5638"},{"key":"e_1_2_5_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.03.428"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.28300","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.28300","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcb.28300","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.28300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T07:50:27Z","timestamp":1714722627000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.28300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,11]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/jcb.28300"],"URL":"https:\/\/doi.org\/10.1002\/jcb.28300","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,11]]},"assertion":[{"value":"2018-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}