{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T22:20:53Z","timestamp":1759616453879,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T00:00:00Z","timestamp":1547769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neuropathic pain, resulting from somatosensory nervous system dysfunction, remains a serious public health problem worldwide. microRNAs are involved in the physiological processes of neuropathic pain. However, the biological roles of miR\u201098 in neuropathic pain development have not been investigated. Therefore, in our current study, we focused on the effects of miR\u201098 in neuropathic pain. It was shown that miR\u201098 was significantly downregulated in chronic sciatic nerve injury (CCI) rat models. In addition, high mobility group A2 (HMGA2) was obviously upregulated in CCI rats. Overexpression of miR\u201098 inhibited neuropathic pain progression, including mechanical and thermal hyperalgesia. By a bioinformatics analysis, HMGA2 was predicted as a direct target of miR\u201098. The negative correlation between miR\u201098 and HMGA2 was validated in our present study. Furthermore, overexpression of miR\u201098 dramatically repressed HMGA2 protein and messenger RNA (mRNA) expression. Neuroinflammation participates in neural\u2010immune interactions, which can contribute to the neuropathic pain development. Meanwhile, we found that inflammatory cytokine (interleukin [IL]\u20106, IL\u20101\u03b2, and COX\u20102) protein expression in rats infected with LV\u2010miR\u201098 was greatly suppressed. Taking these results together, we concluded that miR\u201098 might depress neuropathic pain development through modulating HMGA2.<\/jats:p>","DOI":"10.1002\/jcb.28320","type":"journal-article","created":{"date-parts":[[2019,1,19]],"date-time":"2019-01-19T19:27:21Z","timestamp":1547926041000},"page":"10363-10369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["miR\u201098 acts as an inhibitor in chronic constriction injury\u2010induced neuropathic pain via downregulation of high\u2010mobility group AT\u2010hook 2"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9851-8574","authenticated-orcid":false,"given":"Yang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University Huai'an Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University Huai'an Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Jun","family":"An","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University Huai'an Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University Huai'an Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University Huai'an Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Jian","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University Huai'an Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University Huai'an Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,18]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.051508.135531"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2011.08.014"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.08.013"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-016-2713-8"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02871"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1029"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-1498-7_7"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-018-0492-1"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1015-y"},{"key":"e_1_2_6_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.205"},{"key":"e_1_2_6_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-015-1734-7"},{"key":"e_1_2_6_1_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16-1182"},{"key":"e_1_2_6_1_15_1","doi-asserted-by":"publisher","DOI":"10.4137\/JEN.S32843"},{"key":"e_1_2_6_1_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000455987"},{"key":"e_1_2_6_1_17_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.898788"},{"key":"e_1_2_6_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2008.07.007"},{"key":"e_1_2_6_1_19_1","first-page":"349","article-title":"[Electrologic study of a case of botulism. 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