{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:58:32Z","timestamp":1760101112534,"version":"3.40.4"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T00:00:00Z","timestamp":1550448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Talents Highland of Emergency and Medical Rescue of Guangxi Province in China","award":["GXJZ201510"],"award-info":[{"award-number":["GXJZ201510"]}]},{"name":"National Natural Science Foundation of Guangxi","award":["2017GXNSFBA198049"],"award-info":[{"award-number":["2017GXNSFBA198049"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>), a potent hepatotoxin, is linked to the histopathological outcomes of inflammatory or oxidative stress, and cell death. However, further study of additional dysmetabolism induced by CCl\n<jats:sub>4<\/jats:sub> toxicant has not yet been investigated. In current study, chronical and acute exposures of CCl\n<jats:sub>4<\/jats:sub> in mice were used to unmask the biological molecular mechanism responsible for insulin\u2010dependent metabolic disorder. In experimental methods, a number of biochemical assays were used in assessment of biological impacts on insulin\u2010produced pancreas and insulin\u2010responsive hepatocyte after long\u2010 and short\u2010term exposures of CCl\n<jats:sub>4<\/jats:sub> toxicant, respectively. As a result, data from oral glucose tolerance test showed that CCl\n<jats:sub>4<\/jats:sub> exposures induced glucose tolerance and disrupted blood insulin and glucagon levels time\u2010dependently. Meanwhile, biochemical and histocytological analyses further indicated that CCl\n<jats:sub>4<\/jats:sub> exposures significantly resulted in liver cell damage, induced abnormal changes of hepatic and skeletal glycogen synthesis. In addition, acute CCl\n<jats:sub>4<\/jats:sub>\u2010exposed mice showed reduced functional proteins of glucose transporter 2 (GLUT2), insulin receptor \u03b2, insulin receptor substrate 1, glycogen synthase kinase 3\u03b2 (GSK3\u03b2), p\u2010AKT\n<jats:sup>Ser473<\/jats:sup> associated with AKT signaling pathway in liver cells, whereas acute CCl\n<jats:sub>4<\/jats:sub> exposure downregulated the endogenous expressions of the insulin and glucagon hormonal proteins in the pancreas. Taken together, the current findings highlight that CCl\n<jats:sub>4<\/jats:sub> impaired insulin\u2010dependent glucose homeostasis through modulating hepatocellular AKT signaling pathway in acute CCl\n<jats:sub>4<\/jats:sub> exposure and GLUT2\/GSK3\u03b2 pathway in chronic CCl\n<jats:sub>4<\/jats:sub>\u2010exposed liver cells.<\/jats:p>","DOI":"10.1002\/jcb.28481","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T12:54:53Z","timestamp":1550494493000},"page":"11973-11980","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Adverse impact of carbon tetrachloride on metabolic function in mice"],"prefix":"10.1002","volume":"120","author":[{"given":"Xiaoliu","family":"Liang","sequence":"first","affiliation":[{"name":"College of Pharmacy, Guangxi Medical University  Guangxi Nanning P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ka","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Second People\u2019s Hospital of Nanning City, The Third Affiliated Hospital of Guangxi Medical University  Guangxi Nanning P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meizhen","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Guangxi Medical University  Guangxi Nanning P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4127-7260","authenticated-orcid":false,"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Guangxi Medical University  Guangxi Nanning P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,18]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00426.2010"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v3.i5.99"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12790"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)31805-8"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v5.i3.244"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00199.2012"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.02.051"},{"key":"e_1_2_8_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2013.06.008"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2016.09.036"},{"key":"e_1_2_8_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.12.026"},{"key":"e_1_2_8_1_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000371796"},{"key":"e_1_2_8_1_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000555"},{"key":"e_1_2_8_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-017-0872-7"},{"key":"e_1_2_8_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.11.010"},{"key":"e_1_2_8_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.10.059"},{"key":"e_1_2_8_1_17_1","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2001-7-826"},{"key":"e_1_2_8_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.05.014"},{"key":"e_1_2_8_1_19_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1640013"},{"key":"e_1_2_8_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(14)60076-5"},{"key":"e_1_2_8_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2014.tb00548.x"},{"key":"e_1_2_8_1_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00712.2009"},{"key":"e_1_2_8_1_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S48260"},{"key":"e_1_2_8_1_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27743"},{"key":"e_1_2_8_1_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1979"},{"key":"e_1_2_8_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.11.016"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.28481","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.28481","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcb.28481","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.28481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T18:12:00Z","timestamp":1744567920000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.28481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,18]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1002\/jcb.28481"],"URL":"https:\/\/doi.org\/10.1002\/jcb.28481","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"type":"print","value":"0730-2312"},{"type":"electronic","value":"1097-4644"}],"subject":[],"published":{"date-parts":[[2019,2,18]]},"assertion":[{"value":"2018-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}