{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:35:40Z","timestamp":1761744940975,"version":"3.40.4"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Periodontics Department of Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was conducted on 87 patients with chronic periodontitis (CP), 50 patients with peri\u2010implantitis and 90 periodontally healthy individuals referring to the Department of Periodontics for evaluating the association between Fc gamma\u2010receptor genes polymorphisms with CP and peri\u2010implantitis. After obtaining consent, venous blood samples (5cc) were obtained from patients and DNA was extracted using Miller's salting\u2010out method. Polymerase chain reaction (PCR)\u2010restriction fragment length polymorphism and tetra\u2010primer amplification refractory mutation system\u2010PCR methods were used to assess the polymorphisms of <jats:italic>Fc\u03b3Rs IIa<\/jats:italic>, \n<jats:italic>IIIa<\/jats:italic>, and \n<jats:italic>IIIb<\/jats:italic> genes. Analyzing showed a significant association between specific genotypes with increasing CP and peri\u2010implantitis risks in codominant and dominant models. For \n<jats:italic>Fc\u03b3R IIIa<\/jats:italic>, analyzing revealed a significant association between specific genotypes with increasing CP and peri\u2010implantitis risks in codominant, dominant, and recessive models. For \n<jats:italic>Fc\u03b3R IIIb<\/jats:italic>, we also detected a significant association between specific genotypes with increasing CP and peri\u2010implantitis risks in codominant, dominant, and recessive models (\n<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). According to the results of this study, the \n<jats:italic>FCGRIIa<\/jats:italic> (rs1801274), \n<jats:italic>FCGRIIIa<\/jats:italic> (rs396991), and \n<jats:italic>FCGRIIIb<\/jats:italic> (rs1050501) polymorphisms were significantly associated with CP and peri\u2010implantitis and may have a role in the pathogenesis of these diseases.<\/jats:p>","DOI":"10.1002\/jcb.28486","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T00:52:13Z","timestamp":1553043133000},"page":"12010-12017","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association of Fc gamma\u2010receptor genes polymorphisms with chronic periodontitis and Peri\u2010Implantitis"],"prefix":"10.1002","volume":"120","author":[{"given":"Leila","family":"Saremi","sequence":"first","affiliation":[{"name":"Department of Biology, Science and Research Branch Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4519-8298","authenticated-orcid":false,"given":"Emran","family":"Esmaeilzadeh","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center Iran University of Medical Science Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahereh","family":"Ghorashi","sequence":"additional","affiliation":[{"name":"Sarem Cell Research Center (SCRC) Sarem Women's Hospital Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Sohrabi","sequence":"additional","affiliation":[{"name":"Medical Biology Research Center Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Ekhlasmand Kermani","sequence":"additional","affiliation":[{"name":"Periodontics Department, Dental School Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdi","family":"Kadkhodazadeh","sequence":"additional","affiliation":[{"name":"Periodontics Department, Dental School Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1384.028"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2007.01410b.x"},{"key":"e_1_2_9_1_4_1","first-page":"7","article-title":"Long time follow up of implant therapy and treatment of peri\u2010implantitis","volume":"188","author":"Roos\u2010Jans\u00e5ker A\u2010M","year":"2007","journal-title":"Swed Dent J 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