{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:06:38Z","timestamp":1776744398782,"version":"3.51.2"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T00:00:00Z","timestamp":1551657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High\u2010grade ovarian serous carcinoma (HGS\u2010OvCa), a type of ovarian cancer with poor prognosis due to distant metastasis, is urgently in need of new therapeutic targets. microRNAs (miRNAs), a class of small noncoding RNAs, perform significant roles in tumor progression. Mounting evidence has revealed the aberrant expression of miRNA in various cancers, one of which is HGS\u2010OvCa. Present study planned to investigate that miRNA\u2010301b\u20103p accelerates migration and invasion of high\u2010grade ovarian serous tumor via targeting CPEB3\/EGFR axis. Upregulation of miR\u2010301b\u20103p was uncovered in HGS\u2010OvCa tissues and cell lines, and was identified to be associated with metastasis. The Kaplan\u2010Meier analysis confirmed the association of miR\u2010301b\u20103p with poor prognosis of HGS\u2010OvCa patients. Transwell assay validated the oncogenic effect of miR\u2010301b\u20103p on migration and invasion of HGS\u2010OvCa cells. Cytoplasmic polyadenylation element binding protein 3 (CPEB3) was then identified as a target of miR\u2010301b\u20103p. It was also discovered that CPEB3 was downregulated in HGS\u2010OvCa tissues and cell lines. The Spearman correlation curve presented the negative correlation of CPEB3 expression with miR\u2010301b\u20103p. Furthermore, rescue assays proved that miRNA\u2010301b\u20103p regulated the invasion and migration through CPEB3. Western blot and qRT\u2010PCR analysis showed that miRNA\u2010301b\u20103p induced epidermal growth factor receptor and downstream metastasis\u2010related proteins, p38, and extracellular signal\u2010regulated kinase 1\/2 (ERK1\/2), through CPEB3. To be concluded, these results indicated that miRNA\u2010301b\u20103p accelerated migration and invasion of high\u2010grade ovarian serous tumor via targeting CPEB3\/EGFR axis.<\/jats:p>","DOI":"10.1002\/jcb.28528","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T05:30:40Z","timestamp":1551763840000},"page":"12618-12627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["miRNA\u2010301b\u20103p accelerates migration and invasion of high\u2010grade ovarian serous tumor via targeting CPEB3\/EGFR axis"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2256-5179","authenticated-orcid":false,"given":"Fengying","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gynecology and obstetrics the Fourth Hospital of Jinan Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecology and obstetrics the Fourth Hospital of Jinan Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiming","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Gynecology and obstetrics the Fourth Hospital of Jinan Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinmian","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine the Fourth Hospital of Jinan Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peishu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gynecology and obstetrics Qilu Hospital of Shandong University Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,4]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001867"},{"key":"e_1_2_7_1_3_1","unstructured":"HowladerN.2011. 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