{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:11Z","timestamp":1786977971315,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,3,10]],"date-time":"2019-03-10T00:00:00Z","timestamp":1552176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Guangxi Education Department Research Project","award":["KY2015YB235"],"award-info":[{"award-number":["KY2015YB235"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hepatic function is of great concern in metabolic and immunological homeostasis. Traditionally, medical management to liver damage may benefit from phytomedicine, such as Chinese herbs. In southern China,\n                    <jats:italic>Polygonum perfoliatum L<\/jats:italic>\n                    can contribute to alleviating pathological symptoms of liver disease, such as hepatitis. However, bioactive compounds of hepatoprotection in this herb are still less to be investigated. In this study, clinical data of patients with drug\u2010induced liver injury were collected on the basis of serological analyses. In addition, we extracted and identified total flavonoids from\n                    <jats:italic>Polygonum perfoliatum L<\/jats:italic>\n                    (TFPPL) before implementing biochemical experiments in vivo. In human data, the blood contents of liver function enzymes were visibly elevated, and the percentage of immune cells were abnormally changed. The data from the animal study showed that TFPPL\u2010treated carbon tetrachloride\u2010exposed mice resulted in reduced absolute liver mass and lowered blood levels of liver functional enzymes (alanine transaminase and aspartate transaminase). In enzyme\u2010linked immunosorbent assay, the comparable data indicated that serological tumor necrosis factor \u03b1 (TNF\u2010\u03b1), interleukin 6, and heat shock protein 90 (Hsp90) contents were reduced in TFPPL\u2010treated mice. In histopathological observations, TFPPL\u2010treated mice exhibited reduced hepatocellular Hsp90, TNF\u2010\u03b1, nuclear factor \u03ba\u2010light\u2010chain\u2010enhancer of activated B cells\u2010p65 positive cells, and lowered Bax and caspase\u20103\u2010labeled cells in the livers. Further, intrasplenic integrin \u03b21, 5\u2032\u2010nucleotidase, and antigen KI\u201067 positive cells were increased after TFPPL treatments. Taken together, our present findings demonstrate that herb\u2010extracted TFPPL exert potential hepatoprotective activities against chemical\u2010induced liver damage in mice, possibly through the pharmacological mechanisms of inhibiting inflammatory stress and apoptosis, inactivating Hsp90 bioactivity in the liver, and improving splenic immunocompetence.\n                  <\/jats:p>","DOI":"10.1002\/jcb.28535","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T02:11:24Z","timestamp":1552270284000},"page":"12677-12683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Total flavonoids, extracted from\n                    <i>Polygonum knotweed L<\/i>\n                    , exert beneficial hepatoprotection against liver injury"],"prefix":"10.1002","volume":"120","author":[{"given":"Lingyuan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Pharmacy Affiliated Hospital of Youjiang Medical University for Nationalities Baise China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guikun","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Youjiang Medical University for Nationalities Baise China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Affiliated Hospital of Youjiang Medical University for Nationalities Baise China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiji","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Affiliated Hospital of Youjiang Medical University for Nationalities Baise China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8458-8782","authenticated-orcid":false,"given":"Silu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pharmacy 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