{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:19:13Z","timestamp":1777699153794,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T00:00:00Z","timestamp":1552435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cervical cancer is among the most common type of cancers in women and is associated with human papillomavirus (HPV) infection. Genital warts are also reported to be linked with HPV infection types 11 and 6. In turn, clinical characteristics and morphological features of warts may be useful in the prediction of prognosis and in making treatment decisions. Thus, we have investigated the association of high and low\u2010risk HPVs genotype with genital wart risk, as well as pathological and cytological information in cases recruited from a population\u2010based cohort study of 1380 patients. Patients infected with HPV genotype 6 or 11 had an increased risk of having warts, with OR of 2.34 (95% CI: 0.955\u20105.737, <jats:italic>P<\/jats:italic>\u2009=\u20090.06). Also, this association was enhanced in the presence of high plus low\u2010risk HPV for having genital wart (OR: 2.814; 95%: 1.208\u20106.55, \n<jats:italic>P<\/jats:italic>\u2009=\u20090.017) and cases having high\u2010risk HPV (OR: 2.329; 95% CI: 1.029\u20105.269, \n<jats:italic>P<\/jats:italic>\u2009=\u20090.042). Moreover, we observed patients with genital warts having CIN2\/3, indicating the importance of informing the physician to the patient to prevent more severe lesions. Our data demonstrated that patients with both low\/high\u2010risk HPV types had an increased risk of developing genital warts and persistent infection with HPV was a necessary precursor for the increase in cervical lesions.<\/jats:p>","DOI":"10.1002\/jcb.28557","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T06:35:03Z","timestamp":1552545303000},"page":"12870-12874","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The interaction of high and low\u2010risk human papillomavirus genotypes increases the risk of developing genital warts: A population\u2010based cohort study"],"prefix":"10.1002","volume":"120","author":[{"given":"Malihe","family":"Hasanzadeh","sequence":"first","affiliation":[{"name":"Department of Gynecology Oncology Woman Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzieh","family":"Rejali","sequence":"additional","affiliation":[{"name":"Department of Gynecology Oncology Woman Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Metabolic Syndrome Research Center, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehraneh","family":"Mehramiz","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdieh","family":"Akbari","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Mousavi Seresht","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasaman","family":"Yazdandoost","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saba","family":"Farokhi","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Mahdian","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faezeh","family":"Maleki","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohreh","family":"Emamdadi\u2010Aliabad","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narjes","family":"Jalilvand","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shadi","family":"Khorrami","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Fadaei","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehraneh","family":"Movahedi","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeinab","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Razmi","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toktame","family":"Takamoli","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon A.","family":"Ferns","sequence":"additional","affiliation":[{"name":"Brighton &amp; 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