{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T19:20:08Z","timestamp":1771615208724,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, we aimed to investigate the association between rs4938723 single\u2010nucleotide polymorphism (SNP) and the risk of primary open\u2010angle glaucoma (POAG) in a Chinese population to clarify the molecular mechanism underlying the pathogenesis of POAG. Taqman assays and statistical analyses were utilized to analysis the associations between rs4938723 SNP\/rs1042522 SNP and the risk of POAG. Luciferase assays, in\u2010silicon analyses, real\u2010time PCR, Western Blot, 3\u2010[4,5\u2010dimethylthiazol\u20102\u2010yl]\u20102,5 diphenyl tetrazolium bromide (MTT) assay, and flow cytometry were conducted to establish a molecular pathway underlying the protective effect of rs4938723 T\u2009&gt;\u2009C SNP against the risk of POAG. The maximum intraocular pressure (IOP) was evidently higher in the case group compared with that in the control group. The risk of POAG was evidently decreased among carriers of the CT\/CC genotypes under a dominant model. In addition, the risk of POAG was also significantly decreased in the carriers of the CC genotype. In contrary, no significant association was found between the risk of POAG and the rs1042522 SNP in \n<jats:italic>TP53<\/jats:italic> gene. In addition, rs4938723 (especially rs4938723 T\u2009&gt;\u2009C) SNP could elevate the transcription efficiency of miR\u201034b promoter and the suppression of TP53, a virtual target of miR\u201034b. Therefore, the presence of anti\u2010miR\u201034b suppressed cell proliferation and promoted cell apoptosis, thus establishing a molecular mechanism underlying the protective effect of rs4938723 polymorphism T\u2009&gt;\u2009C against the risk of POAG. Rs4938723 polymorphism T\u2009&gt;\u2009C could reduce the incidence of POAG by downregulating TP53 expression, thus leading to suppressed cell apoptosis and enhanced cell proliferation.<\/jats:p>","DOI":"10.1002\/jcb.28559","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T20:11:18Z","timestamp":1552421478000},"page":"12875-12886","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association between rs4938723 polymorphism and the risk of primary open\u2010angle glaucoma (POAG) in a Chinese population"],"prefix":"10.1002","volume":"120","author":[{"given":"Jian","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Shaanxi Provincial People's Hospital Xi'an Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8670-5954","authenticated-orcid":false,"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Ankang City Central Hospital Ankang Shaanxi 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