{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:24:06Z","timestamp":1778635446478,"version":"3.51.4"},"reference-count":125,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatitis C virus (HCV) is the most prevalent viral pathogen that infects more than 185 million people worldwide. HCV infection leads to chronic liver diseases such as liver cirrhosis and hepatocellular carcinoma. Direct\u2010acting antivirals (DAAs) are the recent combination therapy for HCV infection with reduced side effects than prior therapies. Sustained virological response (SVR) acts as a gold standard marker to monitor the success of antiviral treatment. Older treatment therapies attain 50\u201055% of SVR compared with DAAs which attain around 90\u201095%. The current review emphasizes the recent chemogenomic updates that have been unfolded through structure\u2010based drug design of HCV drug target proteins (NS3\/4A, NS5A, and NS5B) and ligand\u2010based drug design of DAAs in achieving a stable HCV viral treatment strategies.<\/jats:p>","DOI":"10.1002\/jcb.28581","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T00:52:26Z","timestamp":1553043146000},"page":"12167-12181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Review on chemogenomic approaches towards hepatitis C viral targets"],"prefix":"10.1002","volume":"120","author":[{"given":"Arthi","family":"Venkatesan","sequence":"first","affiliation":[{"name":"Department of Integrative Biology School of BioSciences and Technology (SBST), VIT Vellore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6748-739X","authenticated-orcid":false,"given":"Febin","family":"Prabhu Dass J.","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology School of BioSciences and Technology (SBST), VIT Vellore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i29.9633"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-777X.52979"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2523562"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.25885"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/bega.1999.0070"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2006.06.008"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/740138"},{"key":"e_1_2_8_1_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/236148"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3098"},{"key":"e_1_2_8_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26744"},{"key":"e_1_2_8_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30528-0"},{"key":"e_1_2_8_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26744"},{"key":"e_1_2_8_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2011.01.017"},{"key":"e_1_2_8_1_15_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i17.2406"},{"key":"e_1_2_8_1_16_1","first-page":"113","article-title":"Hepatitis C virus proteins: from structure to function","volume":"369","author":"Moradpour D","year":"2013","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_2_8_1_17_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i42.11984"},{"key":"e_1_2_8_1_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182710"},{"key":"e_1_2_8_1_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01480"},{"issue":"5","key":"e_1_2_8_1_20_1","first-page":"305","article-title":"Management of patients who have achieved sustained virologic response for hepatitis C virus infection","volume":"14","author":"Pockros PJ","year":"2018","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_8_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30528-0"},{"key":"e_1_2_8_1_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000486812"},{"key":"e_1_2_8_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(08)70126-9"},{"key":"e_1_2_8_1_24_1","doi-asserted-by":"publisher","DOI":"10.4161\/hv.5.3.6614"},{"key":"e_1_2_8_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.06.084"},{"key":"e_1_2_8_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.02.002"},{"key":"e_1_2_8_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.08.005"},{"key":"e_1_2_8_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.12.072"},{"key":"e_1_2_8_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.03.009"},{"key":"e_1_2_8_1_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.058"},{"key":"e_1_2_8_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270728"},{"key":"e_1_2_8_1_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2008.01058.x"},{"key":"e_1_2_8_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(09)60045-3"},{"key":"e_1_2_8_1_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003155"},{"key":"e_1_2_8_1_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.06.009"},{"key":"e_1_2_8_1_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2009.02064.x"},{"key":"e_1_2_8_1_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811193392101"},{"key":"e_1_2_8_1_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2006\/357259"},{"issue":"5","key":"e_1_2_8_1_39_1","first-page":"316","article-title":"Hepatitis C in a new era: a review of current therapies","volume":"42","author":"Kish T","year":"2017","journal-title":"Pharm Ther"},{"key":"e_1_2_8_1_40_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i8.1133"},{"key":"e_1_2_8_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.09.002"},{"key":"e_1_2_8_1_42_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-011112-140254"},{"key":"e_1_2_8_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62121-2"},{"key":"e_1_2_8_1_44_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i24.2582"},{"key":"e_1_2_8_1_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2011.49"},{"key":"e_1_2_8_1_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2055-6640(20)30691-9"},{"key":"e_1_2_8_1_47_1","first-page":"241","article-title":"Simeprevir for the treatment of hepatitis C virus infection","volume":"7","author":"Izquierdo L","year":"2014","journal-title":"Pharmacogenomics Pers Med"},{"key":"e_1_2_8_1_48_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1012912"},{"key":"e_1_2_8_1_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2011.07.006"},{"key":"e_1_2_8_1_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.69.4.2534-2539.1995"},{"key":"e_1_2_8_1_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81351-3"},{"key":"e_1_2_8_1_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.9.6465-6471.1997"},{"key":"e_1_2_8_1_53_1","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2008.2988"},{"key":"e_1_2_8_1_54_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.10.7152"},{"key":"e_1_2_8_1_55_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R110.125294"},{"key":"e_1_2_8_1_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.624"},{"key":"e_1_2_8_1_57_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2001.1229"},{"key":"e_1_2_8_1_58_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.01.002"},{"key":"e_1_2_8_1_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1110534108"},{"key":"e_1_2_8_1_60_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02630-12"},{"key":"e_1_2_8_1_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.05.015"},{"key":"e_1_2_8_1_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb5006118"},{"key":"e_1_2_8_1_63_1","doi-asserted-by":"publisher","DOI":"10.1080\/23808993.2018.1424535"},{"key":"e_1_2_8_1_64_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/751057"},{"key":"e_1_2_8_1_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21836"},{"key":"e_1_2_8_1_66_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111289200"},{"key":"e_1_2_8_1_67_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.10.6055-6061.2003"},{"key":"e_1_2_8_1_68_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404761200"},{"key":"e_1_2_8_1_69_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00253-11"},{"key":"e_1_2_8_1_70_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407787200"},{"key":"e_1_2_8_1_71_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.116"},{"key":"e_1_2_8_1_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03580"},{"key":"e_1_2_8_1_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20851"},{"key":"e_1_2_8_1_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21809"},{"key":"e_1_2_8_1_75_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02524-06"},{"key":"e_1_2_8_1_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24594"},{"key":"e_1_2_8_1_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci400631n"},{"key":"e_1_2_8_1_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.2456"},{"key":"e_1_2_8_1_79_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2016.1161028"},{"key":"e_1_2_8_1_80_1","doi-asserted-by":"publisher","DOI":"10.3390\/v7072808"},{"key":"e_1_2_8_1_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.10.008"},{"key":"e_1_2_8_1_82_1","doi-asserted-by":"publisher","DOI":"10.22159\/ijpps.2016v8i11.13965"},{"key":"e_1_2_8_1_83_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152606776056724"},{"key":"e_1_2_8_1_84_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X13515825"},{"key":"e_1_2_8_1_85_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00444-08"},{"key":"e_1_2_8_1_86_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn085"},{"key":"e_1_2_8_1_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.10.009"},{"key":"e_1_2_8_1_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04449-3"},{"key":"e_1_2_8_1_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/minf.201800050"},{"key":"e_1_2_8_1_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6634-9_5"},{"key":"e_1_2_8_1_91_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.112.007336"},{"key":"e_1_2_8_1_92_1","doi-asserted-by":"publisher","DOI":"10.2174\/157340911793743547"},{"key":"e_1_2_8_1_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-011-9518-x"},{"key":"e_1_2_8_1_94_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules200713384"},{"key":"e_1_2_8_1_95_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026614666140929124445"},{"key":"e_1_2_8_1_96_1","doi-asserted-by":"publisher","DOI":"10.4103\/0250-474X.102537"},{"key":"e_1_2_8_1_97_1","doi-asserted-by":"publisher","DOI":"10.2174\/157340911795677602"},{"key":"e_1_2_8_1_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06119-y"},{"key":"e_1_2_8_1_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.08.021"},{"key":"e_1_2_8_1_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemolab.2016.03.015"},{"key":"e_1_2_8_1_101_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087077"},{"key":"e_1_2_8_1_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms141122845"},{"key":"e_1_2_8_1_103_1","first-page":"1","article-title":"Identification of potent hepatitis C virus RdRp inhibitors by structure based drug designing","volume":"1","author":"Sundarrajan S","year":"2014","journal-title":"J Bioinf Cheminf"},{"key":"e_1_2_8_1_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms12085304"},{"key":"e_1_2_8_1_105_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2017-0124"},{"key":"e_1_2_8_1_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-102081-4.00016-2"},{"key":"e_1_2_8_1_107_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.11.70"},{"key":"e_1_2_8_1_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2010.03.013"},{"key":"e_1_2_8_1_109_1","first-page":"pp. 67","volume-title":"ACS Symposium Series","author":"Willett P","year":"2016"},{"key":"e_1_2_8_1_110_1","doi-asserted-by":"publisher","DOI":"10.1897\/01-171"},{"key":"e_1_2_8_1_111_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102105\u201013\u2010S17\u2010S5"},{"key":"e_1_2_8_1_112_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557517666170315150116"},{"key":"e_1_2_8_1_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26262"},{"key":"e_1_2_8_1_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2012.04.016"},{"key":"e_1_2_8_1_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11224-018-1141-1"},{"key":"e_1_2_8_1_116_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148181"},{"key":"e_1_2_8_1_117_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci400644r"},{"key":"e_1_2_8_1_118_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009482"},{"key":"e_1_2_8_1_119_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1013086"},{"key":"e_1_2_8_1_120_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010494"},{"key":"e_1_2_8_1_121_1","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2016.52.2.2449840"},{"key":"e_1_2_8_1_122_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3025"},{"issue":"11","key":"e_1_2_8_1_123_1","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1001\/jama.2016.2070","article-title":"COmbination treatment for hcv","volume":"315","author":"Voelker R","year":"2016","journal-title":"JAMA"},{"issue":"5","key":"e_1_2_8_1_124_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/01.NAJ.0000482958.70682.bd","article-title":"A new treatment for chronic hepatitis C","volume":"116","author":"Aschenbrenner DS","year":"2016","journal-title":"Am J Nurs"},{"issue":"9","key":"e_1_2_8_1_125_1","first-page":"6","article-title":"New triple therapy for chronic hepatitis C: real life clinical experience in a community setting","volume":"72","author":"Akiyama MJ","year":"2013","journal-title":"Hawaii J Med Public Health"},{"key":"e_1_2_8_1_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(04)63002-8"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.28581","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcb.28581","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.28581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T11:16:06Z","timestamp":1725966966000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.28581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,19]]},"references-count":125,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/jcb.28581"],"URL":"https:\/\/doi.org\/10.1002\/jcb.28581","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,19]]},"assertion":[{"value":"2018-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}