{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T12:46:33Z","timestamp":1782737193592,"version":"3.54.5"},"reference-count":74,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T00:00:00Z","timestamp":1554336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Deregulation of noncoding RNAs, microRNAs (miRNAs) and long noncoding RNA (lncRNA), are implicated in the initiation and progression of gastric cancer (GC). This study is a pilot case\u2010control study carried out on 75 subjects, 40 of them were <jats:italic>Helicobacter pylori<\/jats:italic>\u2010gastric ulcer patients and 35 were GC patients recruited from the Gastrointestinal Endoscopy Unit in Al\u2010Kasr Al\u2010Aini Hospital, Cairo University in Egypt. Real\u2010time PCR was performed to evaluate the expression level of serum miR\u2010204, miR\u2010182, and lncRNA H19 in patients with peptic ulcer\u2010progressed GC vs nonprogressed peptic ulcer patients. Fibroblast growth factor 18 (FGF\u201018)\/FGF receptor 2 (FGFR2) expression and their downstream immunological and inflammatory signaling markers were assessed and their association with the addressed noncoding RNAs investigated. As regards miR\u2010204 and miR\u2010182, they were significantly increased (12.5 and 2.6 folds, respectively) in GU samples, compared with those of healthy control levels. The elevated levels of these miRNAs were significantly de\u2010escalated in GC samples compared with GU and the fold decrease valued 2.2 fold for miR\u2010204 and 1.8 folds for miR\u2010182. On the other hand, the significant escalation in the level of lnRNA H19 in GU recorded a 16.6 fold increase and further elevation in its levels was evident in GC samples. The herein assessed miRNAs are correlated with disease duration and FGFR2 with miR\u2010182 being significantly correlated with all inflammatory markers, TAC, INF\u2010\u03b3, matrix metallopeptidase 9, and FGF\u201018. In terms of diagnostic accuracy of assessed miRNAs (stages III to IV), the receiver operating characteristic analysis indicated that serum lncRNA H19 showed the highest diagnostic accuracy (95.5%), specificity (100%), and sensitivity (90.9%), compared with miR\u2010204 and miR\u2010182, which showed the same specificity (60%), sensitivity (72.7%), and diagnostic accuracy (68.8%). Our findings conclude that lnRNA H19, miR\u2010204, and miR\u2010182 may function as novel prospective plasma biomarkers to detect GC and its progression from <jats:italic>H. pylori<\/jats:italic>\u2010peptic ulcer, which would be helpful to improve the theranostics of GC.<\/jats:p>","DOI":"10.1002\/jcb.28620","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T07:20:59Z","timestamp":1554362459000},"page":"13464-13477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The expression profiling of circulating miR\u2010204, miR\u2010182, and lncRNA H19 as novel potential biomarkers for the progression of peptic ulcer to gastric cancer"],"prefix":"10.1002","volume":"120","author":[{"given":"Waleed A.","family":"Mohamed","sequence":"first","affiliation":[{"name":"Department of Chemistry Kasr El Aini Teaching Hospital, Cairo University Cairo 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