{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:40:25Z","timestamp":1776922825795,"version":"3.51.2"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T00:00:00Z","timestamp":1554163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Matrine might play a vital role in cardiovascular diseases progression and treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to explore the protective effects and potential mechanism of matrine against diabetic cardiomyopathy (DCM) in rat model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A rat model of DCM was induced by streptozotocin, which were then divided into two groups and treated with matrine. Inflammatory cytokines were investigated in serum and myocardial cells after matrine administration. The effects of matrine on cardiac reactive oxygen species (ROS) generation, Malondialdehyde (MDA) levels, and Glutathione peroxidase (GPx), PPAR\u03b31 activity were detected in myocardial cells. The protein kinase RNA\u2010like endoplasmic reticulum kinase (PERK) signal pathway in endoplasmic reticulum stress was studied to elaborated protective effects of matrine in DCM rat by Western blot analysis. Fasting blood glucose and hemodynamic parameters were analyzed after treatment with matrine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Matrine\u2010inhibited expression levels of inflammatory cytokines of tumor necrosis factor alpha (TNF\u2010\u03b1) and interleukin 6. Matrine administration decreased ROS generation, MDA, and transforming growth factor beta levels, and Peroxisome proliferator\u2010activated receptor beta (PPAR\u03b2) and Peroxisome proliferator\u2010activated receptor\u03b3 1 (PPAR\u03b31) activity. Matrine administration also significantly inhibited PERK expression. Endogenic expression of PERK canceled matrine\u2010induced apoptosis of myocardial cells. Notably, treatment with matrine significantly decreased nonfasting blood glucose levels and improved hemodynamic parameters of DCM rat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Matrine may be a promising agent for the treatment of DCM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.28632","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T17:09:47Z","timestamp":1554224987000},"page":"13573-13582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Matrine improves diabetic cardiomyopathy through TGF\u2010\u03b2\u2010induced protein kinase RNA\u2010like endoplasmic reticulum kinase signaling pathway"],"prefix":"10.1002","volume":"120","author":[{"given":"Huijuan","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Cardiology Dezhou People's Hospital Dezhou 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