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The role of 15\u2010LOX has been demonstrated in atherosclerosis as well as other inflammatory diseases. In the present study, drug\u2010like compounds were first screened from a set of anti\u2010inflammatory phytochemicals based on Lipinski's rule of five (ROF) and in silico toxicity filters. Two lead compounds\u2010quinine (QUIN) and rutaecarpine (RUT) were shortlisted by analyzing molecular interactions and binding energies of the filtered compounds with the target using molecular docking. Molecular dynamics simulation studies indicate stable trajectories of apo_15\u2010LOX and docked complexes (15\u2010LOX_QUIN and 15\u2010LOX_RUT). In vitro 15\u2010LOX inhibition studies shows that both QUIN and RUT have lower inhibitory concentration (IC<jats:sub>50<\/jats:sub>) value than the control (quercetin). Both QUIN and RUT exhibit moderate antioxidant activities. The cell viability study of these compounds suggests no significant toxicity in HEK\u2010293 cell lines. Further, QUIN and RUT both did not show any inhibition against selected Gram\u2010positive and Gram\u2010negative bacterial species. Thus, based on our present findings, rutaecarpine and quinine may be suggested as promising 15\u2010LOX inhibitor for the prevention of the atherosclerosis development.<\/jats:p>","DOI":"10.1002\/jcb.28634","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T06:24:17Z","timestamp":1554186257000},"page":"13598-13613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Bioprospection of anti\u2010inflammatory phytochemicals suggests rutaecarpine and quinine as promising 15\u2010lipoxygenase inhibitors"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4612-9008","authenticated-orcid":false,"given":"Arun Bahadur","family":"Gurung","sequence":"first","affiliation":[{"name":"Computational Biology Laboratory, Department of Biotechnology and Bioinformatics North\u2010Eastern Hill University Shillong Meghalaya India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pezaiwi","family":"Pamay","sequence":"additional","affiliation":[{"name":"Computational Biology Laboratory, Department of Biotechnology and Bioinformatics North\u2010Eastern Hill University Shillong Meghalaya India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debabrata","family":"Tripathy","sequence":"additional","affiliation":[{"name":"Genetics and Molecular biology Laboratory, Department of Biotechnology and Bioinformatics North\u2010Eastern Hill University Shillong Meghalaya India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koel","family":"Biswas","sequence":"additional","affiliation":[{"name":"Microbiology Laboratory, Department of Biotechnology and Bioinformatics North\u2010Eastern Hill University Shillong Meghalaya India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anupam","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Genetics and Molecular biology Laboratory, Department of Biotechnology and Bioinformatics North\u2010Eastern Hill University Shillong Meghalaya India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.R.","family":"Joshi","sequence":"additional","affiliation":[{"name":"Microbiology Laboratory, Department of Biotechnology and Bioinformatics North\u2010Eastern Hill University Shillong Meghalaya India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atanu","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Computational Biology Laboratory, Department of Biotechnology and Bioinformatics North\u2010Eastern Hill University Shillong Meghalaya India"},{"name":"Bioinformatics Centre North\u2010Eastern Hill University Shillong Meghalaya India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4]]},"reference":[{"key":"e_1_2_9_1_2_1","unstructured":"World Health Organization (WHO). 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