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The mice were subjected to myocardial I\/R with or without miR\u2010193b pretreatment. The infarct size and myocardial enzymes were detected. The terminal deoxynucleotidyl transferase dUTP nick\u2010end labeling assay was conducted to investigate the effect of miR\u2010193b on cardiomyocyte apoptosis. The expression levels of miR\u2010193b and mastermind\u2010like 1 (MAML1) were validated by quantitative real\u2010time polymerase chain reaction and Western blot analysis. The results suggested that the miR\u2010193b expression level was significantly downregulated in the myocardium with I\/R injury compared with control group. miR\u2010193b overexpression is able to reduce infarct size and myocardial enzymes after myocardial I\/R injury. Furthermore, overexpression of miR\u2010193b could alleviate the apoptosis level after myocardial I\/R injury. Taken together, the present study demonstrated that upregulated miRNA\u2010193b alleviated myocardial I\/R injury via targeting MAML1.<\/jats:p>","DOI":"10.1002\/jcb.28684","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T06:45:25Z","timestamp":1555483525000},"page":"14088-14094","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["microRNA\u2010193b protects against myocardial ischemia\u2010reperfusion injury in mouse by targeting mastermind\u2010like 1"],"prefix":"10.1002","volume":"120","author":[{"given":"Jinzhu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Linyi Central Hospital Linyi Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Linyi Central Hospital Linyi Shandong 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