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In this study, we evaluated the therapeutic potential and mechanism of ADSCs stereotactic transplantation in intracerebral hemorrhage (ICH) mice model and hemin\u2010treated astrocytes. Mice were divided into three groups: sham group, ICH\u2009+\u2009PBS group, and ICH\u2009+\u2009ADSC group. Mice in ICH\u2009+\u2009ADSC group received ADSCs cell suspension stereotactic transplantation into the area beside the bleeding region. Astrocytes were divided into three groups: control group, hemin group, and hemin\u2009+\u2009ADSC group. Astrocytes in hemin\u2009+\u2009ADSC group were cultured in ADSCs\u2010astrocyte no\u2010contact coculture system and treated with 30\u2009\u03bcM hemin solution. The results showed that ADSCs stereotactic transplantation improved functional outcomes and reduced cell apoptosis after ICH. Moreover, ADSCs stereotactic transplantation could alleviate brain edema and inflammation and AQP4 protein expression contributed to the alleviation of brain edema. In addition, mitogen\u2010activated protein kinase (MAPK) pathways, including p38\/MAPK pathway and c\u2010Jun N\u2010terminal kinase pathway, were involved in AQP4 modulation by ADSCs transplantation in ICH. In conclusion, ADSCs transplantation could alleviate the nervous tissue injury, reduce cell apoptosis, and relieve brain edema in ICH. And the edema regulation effect of ADSCs transplantation is associated with inhibition of inflammation and AQP4 protein expression.<\/jats:p>","DOI":"10.1002\/jcb.28693","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T06:56:11Z","timestamp":1554792971000},"page":"14372-14382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Adipose\u2010derived mesenchymal stem cells stereotactic transplantation alleviate brain edema from intracerebral hemorrhage"],"prefix":"10.1002","volume":"120","author":[{"given":"Ye","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tongji 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