{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:17:36Z","timestamp":1762543056267,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Coronary artery disease (CAD) is one of the cardiovascular diseases, which is caused by a reduced amount of oxygen and blood that goes to the heart. CAD includes stable angina, unstable angina, myocardial infarction, and sudden cardiac death. It is a common cause of death in both men and women. The environmental and genetic factors are involved in the development of CAD. Multiple gene polymorphisms are risk factors of CAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the association between <jats:italic>EL 584C\/T<\/jats:italic> polymorphism, CAD risk, and lipid profile in an Egyptian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a case\u2010control study. The patients were classified into three groups: Group A: Control group, this group included 42 apparently healthy people. Group B: included 42 subjects diagnosed with previous myocardial infarction (MI). Group C: included 42 subjects diagnosed with unstable angina (UA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequencies of <jats:italic>TT<\/jats:italic> and <jats:italic>CT<\/jats:italic> genotypes and <jats:italic>T<\/jats:italic> allele were higher in control healthy individuals than CAD patients. In addition, the risk of CAD was significantly lower in individuals carrying <jats:italic>T<\/jats:italic> allele (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). Serum high\u2010density lipoprotein (HDL) levels were significantly higher in healthy individuals and CAD patients (MI and UA patients) carrying <jats:italic>EL 584 T allele<\/jats:italic> compared with those carrying <jats:italic>CC<\/jats:italic> genotype (<jats:italic>P\u2009<\/jats:italic>\u2264 <jats:italic>\u2009<\/jats:italic>0.001). By multiple logistic regression, we found that the protective effect of <jats:italic>T<\/jats:italic> allele remained significant (<jats:italic>P<\/jats:italic>\u2009=\u20090.005) and it decreased the risk of CAD independent of plasma HDL levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was a significant difference between <jats:italic>584C\/T<\/jats:italic> polymorphism in the <jats:italic>EL<\/jats:italic> gene and CAD and HDL level. <jats:italic>T<\/jats:italic>\u2010allele carriers had a higher HDL level and were protected from CAD. <jats:italic>T<\/jats:italic> allele was significantly associated with the decreased risk of CAD independent of plasma HDL levels.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.28697","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T06:35:36Z","timestamp":1556174136000},"page":"14414-14420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association of <i>584C\/T<\/i> polymorphism in <i>endothelial lipase<\/i> gene with risk of coronary artery disease"],"prefix":"10.1002","volume":"120","author":[{"given":"Ismail Zaki","family":"Elnaggar","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7407-1608","authenticated-orcid":false,"given":"Samia","family":"Hussein","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Ibrahem","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman Ahmed","family":"Abdelaziz","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,24]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135683"},{"key":"e_1_2_6_1_3_1","first-page":"683","article-title":"On coronary heart disease risk rs20455 polymorphism KIF6 of M. 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