{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:33:43Z","timestamp":1773297223797,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T00:00:00Z","timestamp":1555459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diethylenetriamine penta\u2010acetic acid (DTPA), when complexed with a gamma (\u03b3)\u2010emitter radioisotope like <jats:sup>99m<\/jats:sup>Tc, is used for renal function diagnosis and many other diagnostic applications. The main aim of this study was to develop a novel and versatile single\u2010step methodology for the synthesis of a new <jats:sup>177<\/jats:sup>Lu\u2010labeled radiopharmaceutical with high radiochemical yield, which can be used for diagnostic purposes and therapeutic purposes also. The single and well\u2010defined <jats:sup>177<\/jats:sup>Lu\u2010DTPA complex was radiochemically characterized by paper chromatography, thin\u2010layer chromatography, high\u2010performance liquid chromatography, and electrophoresis techniques. Dependence of the labeling yield of <jats:sup>177<\/jats:sup>Lu\u2010DTPA complex on different factors was studied in detail. Biological evaluation was also performed in a normal rabbit by developing images under a \u03b3 camera at various time intervals. More than 99% labeling yield was obtained by reacting DTPA with <jats:sup>177<\/jats:sup>Lu at specific conditions (pH 7.0, 15 minutes reaction time at 100 \u00b0C). <jats:sup>177<\/jats:sup>Lu\u2010DTPA complex showed high stability both at room temperature and in vitro. Biodistribution studies in normal mice indicated the fractional renal uptake of intravenously administered <jats:sup>177<\/jats:sup>Lu\u2010DTPA complex, which reached in the kidneys within 2\u20103 minutes. Scintigraphy showed rapid clearance from the body. Based on these results, we propose that <jats:sup>177<\/jats:sup>Lu\u2010DTPA complex might be used as an ideal candidate for functional evaluation of kidneys and the urinary tract, especially when needed to be transported to long\u2010range consumer sites, because of its suitable half\u2010life.<\/jats:p>","DOI":"10.1002\/jcb.28712","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T19:44:22Z","timestamp":1555530262000},"page":"14510-14517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Radiosynthesis, radiochemical, and biological characterization of <sup>177<\/sup>Lu\u2010labeled diethylenetriamine penta\u2010acetic acid"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9474-1923","authenticated-orcid":false,"given":"Muhammad U.","family":"Akbar","sequence":"first","affiliation":[{"name":"Department of Chemistry Government College 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