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HSC\u2010T6 cells were activated by platelet\u2010derived growth factor (PDGF) stimulation, and then the effects of MH on cell viability, cytomembrane integrity, colony, migration, apoptosis, and cell cycle were detected. Moreover, the regulative mechanism of MH on HSCs was investigated by detecting the activation of the extracellular signal\u2010regulated kinase (ERK1\/2) signaling pathway. The results showed that MH significantly inhibited HSC\u2010T6 cell viability and proliferation in a concentration\u2010dependent manner. It notably promoted the release of lactate dehydrogenase, destroying cell membrane integrity. MH also markedly inhibited HSC\u2010T6 cell clonogenicity and migration. Moreover, MH treatment significantly induced cell apoptosis and arrested cell cycle at the G2 phase. The further study showed that MH inhibited the expression of ERK1, ERK2, c\u2010fos, c\u2010myc, and Ets\u20101, blocking the ERK1\/2 pathway. 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