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Breast cancer risk factors include smoking, alcohol consumption, personal and family history, hypertension, and hormone therapy, long\u2010term use of nonsteroidal anti\u2010inflammatory drugs and tobacco usage. Surgery, chemotherapy, radiotherapy, immunotherapy, and neoadjuvant therapy are the current means for breast cancer treatment. Despite hormonal agents and chemotherapy, which have beneficial effects on lowering breast cancer death rate, the reaction of different people to these treatments is still a challenging point. Melatonin (N\u2010acetyl\u20105\u2010methoxy tryptamine) is a methoxy indole compound that is mainly secreted by the pineal gland at night; it is as an antioxidant, anti\u2010inflammatory, and oncostatic agent. On the basis of recent studies, melatonin has antitumor properties on different cancer types and it may suppress cancer development in vitro and as well as in animal models. It is suggested that melatonin inhibits the development of breast cancer by various mechanisms. This paper summarizes the roles of melatonin in breast cancer treatment from the aspect of its molecular actions.<\/jats:p>","DOI":"10.1002\/jcb.28832","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T06:44:56Z","timestamp":1556693096000},"page":"12208-12215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Melatonin is an appropriate candidate for breast cancer treatment: Based on known molecular mechanisms"],"prefix":"10.1002","volume":"120","author":[{"given":"Negin","family":"Amin","sequence":"first","affiliation":[{"name":"Research Center for Biochemistry and Nutrition in Metabolic Diseases Kashan University of Medical Sciences Kashan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana","family":"Shafabakhsh","sequence":"additional","affiliation":[{"name":"Research Center for Biochemistry and Nutrition in Metabolic Diseases Kashan University of 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