{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T03:05:20Z","timestamp":1773803120173,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"crossref","award":["931368"],"award-info":[{"award-number":["931368"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human T\u2010cell lymphotropic virus type 1 (HTLV\u20101)\u2010associated myelopathy\/tropical spastic paraparesis (HAM\/TSP) disease is a chronic neuroinflammatory disease, which is associated with HTLV\u20101 infection. There is no effective and satisfactory treatment of HAM\/TSP. It has been shown that curcumin exhibits modulatory effects on apoptosis and cytotoxicity\u2010related molecules in HAM\/TSP patients. In the present study, we examined the effect of curcumin on the gene expression of caspase\u20108, caspase\u201010, and anti\u2010apoptotic protein c\u2010FLIP, in HAM\/TSP patients. Furthermore, we compared the expression of these molecules between HAM\/TSP and asymptomatic carriers.\u00a0Real\u2010time\u00a0PCR was performed to examine the mRNA expression of caspase\u20108, caspase\u201010, and c\u2010FLIP in studied groups. The mRNA expression of caspase\u20108 and caspase\u201010\u00a0was\u00a0similar before and after curcumin treatment in HAM\/TSP patients (<jats:italic>P\u2009<\/jats:italic>&gt;\u20090.05). The mRNA expression of c\u2010FLIPL and c\u2010FLIPs was higher after curcumin treatment compared with before treatment and significant differences were observed between the two groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.004 and <jats:italic>P<\/jats:italic>\u2009=\u20090.044, respectively).\u00a0The mRNA expression levels of caspase\u20108, caspase\u201010, c\u2010FLIPL, and\u00a0c\u2010FLIPs\u00a0were not statistically significant between HAM\/TSP patients and asymptomatic carriers (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><jats:p>In conclusion, our results showed that curcumin increased the expression of c\u2010FLIP in HAM\/TSP patients which might suggest that, this molecule is involved in the apoptosis of HTLV\u20101\u2010infected cells. Further studies with large sample size could be useful to clarify the role of this supplement in HAM\/TSP patients.<\/jats:p>","DOI":"10.1002\/jcb.28843","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T03:50:01Z","timestamp":1557460201000},"page":"15740-15745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Curcumin increased the expression of c\u2010FLIP in HTLV\u20101\u2010associated myelopathy\/tropical spastic paraparesis (HAM\/TSP) patients"],"prefix":"10.1002","volume":"120","author":[{"given":"Zohreh","family":"Poursina","sequence":"first","affiliation":[{"name":"Immunology Research Center, Inflammation and Inflammatory Diseases Division, Faculty of Medicine Mashhad University of Medical Sciences Mashhad 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