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However, metabolic imbalance associated with SHPT is not well understood.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 15 SHPT patients with an intact parathyroid hormone (iPTH) level\u2009>\u2009600\u2009pg\/mL were set as preoperative (PR) group, 15 age\u2010 and gender\u2010matched controls who had undergone parathyroidectomy plus forearm transplantation because of hyperparathyroidism and achieved an iPTH level <150\u2009pg\/mL were set as postoperative (PO) group. Metabolite profiling of these 30 uremic patients and five healthy controls (HC) was performed using ultra performance liquid chromatography\u2010mass spectrometry.<\/jats:p><\/jats:sec>Results<\/jats:title>Five differential metabolites, including allyl isothiocyanate, L<\/jats:sc>\u2010phenylalanine, D<\/jats:sc>\u2010Aspartic acid, indoleacetaldehyde, and D<\/jats:sc>\u2010galactose correlated with PTH were identified in this study. Taking them as a biomarker signature, PR group can be distinguished from HC group with an area under the curve (AUC) of 0.947 (95% CI, 0.76\u20101) and PO group with an AUC of 0.6 (95% CI, 0.38\u20100.807).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The serum metabolome correlated with PTH is successfully demonstrated for a better understanding of the pathogenesis of SHPT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.28846","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T05:58:39Z","timestamp":1557381519000},"page":"15766-15775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Plasma metabolite biomarkers related to secondary hyperparathyroidism and parathyroid hormone"],"prefix":"10.1002","volume":"120","author":[{"given":"Qixia","family":"Shen","sequence":"first","affiliation":[{"name":"Kidney Disease Center, The First Affiliated Hospital, College of Medicine Zhejiang 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