{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T21:15:24Z","timestamp":1757452524732,"version":"3.37.3"},"reference-count":66,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T00:00:00Z","timestamp":1557619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heart disease such as myocardial infarction is the first cause of mortality in all countries. Today, cardiac cell\u2010based therapy using de novo produced cardiac cells is considered as a novel approach for cardiac regenerative medicine. Recently, an alchemy\u2010like approach, known as direct reprogramming or direct conversion, has been developed to directly convert somatic cells to cardiac cells in vitro and in vivo. This cellular alchemy is a short\u2010cut and safe strategy for generating autologous cardiac cells, and it can be accomplished through activating cardiogenesis\u2010 or pluripotency\u2010related factors in noncardiac cells. Importantly, pluripotency factors\u2010based direct cardiac conversion, known as partial reprogramming, is shorter and more efficient for cardiomyocyte generation in vitro. Today, this strategy is achievable for direct conversion of mouse and human somatic cells to cardiac lineage cells (cardiomyocytes and cardiac progenitor cells), using transgene free, chemical\u2010based approaches. Although, heart\u2010specific partial reprogramming seems to be challenging for in vivo conversion of cardiac fibroblasts to cardiac cells, but whole organism\u2010based in vivo partial reprogramming ameliorates cellular and physiological hallmarks of aging and prolongs lifespan in mouse. Notably, cardiac cells produced using partial reprogramming strategy can be a useful platform for disease modeling, drug screening and cardiac cell\u2010based therapy, once the safety issues are overcome. Herein, we discuss about all progresses in de novo production of cardiac cells using partial reprogramming\u2010based direct conversion, as well as give an overview about the potential applications of this strategy in vivo and in vitro.<\/jats:p>","DOI":"10.1002\/jcb.28900","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T06:16:59Z","timestamp":1557728219000},"page":"14247-14261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Partial reprogramming as a therapeutic approach for heart disease: A state\u2010of\u2010the\u2010art review"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8268-7234","authenticated-orcid":false,"given":"Mahmood","family":"Talkhabi","sequence":"first","affiliation":[{"name":"Department of Animal Sciences and Biotechnology, Faculty of Life Sciences and Biotechnology Shahid Beheshti University Tehran 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