{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:13:43Z","timestamp":1790957623055,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Student's Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Ankylosing spondylitis (AS) is an inflammatory rheumatic disease with increased bone mass in the main sites of inflammation. Regulatory T (Treg) cells have been reported to involve in pathology of AS. This study designed at investigating the effects of nanocurcumin on Treg cell responses in peripheral blood (PB) of AS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Test group including 12 AS patients received nanocurcumin daily for 4 months and control group including 12 patients received placebo. The frequency of Treg was measured by flow cytometry. The expression levels of FoxP3 and several associated microRNAs (miRNAs; miR\u201027, miR\u201017, and miR\u2010146a) and cytokines including Interleukin\u201010 (IL\u201010), TGF\u2010\u03b2, and IL\u20106 were assessed by real\u2010time polymerase chain reaction. Furthermore, enzyme\u2010linked immunosorbent assay was done to determine the secretion levels of cytokines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After treatment with nanocurcumin the frequency of Treg cells in AS patients increased significantly. The RT\u2010PCR data indicated that the expression of miR\u201017 and miR\u201027 were significantly decreased following nanocurcumin treatment while miR\u2010146a and FoxP3 were significantly increased. Moreover, nanocurcumin\u2010treated group had high levels of IL\u201010 and TGF\u2010\u03b2 and low levels of IL\u20106 production than control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings suggested that dysregulation of Treg cells in PB influences the AS development and nanocurcumin therapy could regulate the Treg cells, and so could be useful in the treatment of AS and may be other autoimmune diseases.<\/jats:p><jats:p>This study is registered with IRCT.ir, number IRCT2017052927520N7.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.28901","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T03:50:34Z","timestamp":1557460234000},"page":"103-110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["The effects of nanocurcumin on Treg cell responses and treatment of ankylosing spondylitis patients: A randomized, double\u2010blind, 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