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Fibroblasts\u2010like synoviocytes (FLS), major cells in the synovium, together with infiltrated leukocytes, contribute greatly to RA progression. In our study, we hypothesized that geldanamycin (GA), a cancer drug might be able to inhibit RA FLS growth. To test the idea, RA FLS were isolated and cultured for cancer drug test. The results showed that GA can specifically inhibit the growth of RA FLS compared with normal FLS. Essentially, GA was found to promote reactive oxygen species production in RA FLS and induce programmed cell death. The annexinV\/propidium iodide and terminal deoxynucleotidyl transferase dUTP nick\u2010end labeling staining confirmed that GA can directly induce apoptosis and subsequently inhibit the growth of RA FLS, which was also confirmed by Western blot assay. In addition, our data demonstrated that inflammation was inhibited by suppressed nuclear factor \u03baB signaling pathway. The therapeutic effect of GA was explored in collagen\u2010induced arthritis mice. In short, GA was a promising drug for the treatment of RA by specifically inhibiting the proliferation and inflammation of RA FLS.<\/jats:p>","DOI":"10.1002\/jcb.28906","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T14:31:14Z","timestamp":1557844274000},"page":"16254-16263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Geldanamycin induces apoptosis and inhibits inflammation in fibroblast\u2010like synoviocytes isolated from rheumatoid arthritis patients"],"prefix":"10.1002","volume":"120","author":[{"given":"Cuili","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology China\u2010Japan Union Hospital of Jilin University Changchun Jilin P.R. 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