{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:17:27Z","timestamp":1791001047626,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T00:00:00Z","timestamp":1558051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T00:00:00Z","timestamp":1558051200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"University Grant Commission (UGC), Government of India","award":["201213-MANF-2012-13-MUS-UTT-14306"],"award-info":[{"award-number":["201213-MANF-2012-13-MUS-UTT-14306"]}]},{"name":"Integral University","award":["IU\/R&D\/2018-MCN000446"],"award-info":[{"award-number":["IU\/R&D\/2018-MCN000446"]}]},{"name":"University Grant Commission"},{"name":"Government of India for providing Senior Research Fellowship","award":["201213-MANF-2012-13-MUS-UTT-14306"],"award-info":[{"award-number":["201213-MANF-2012-13-MUS-UTT-14306"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Onosma echioides<\/jats:italic>\n                    Linn (Boraginaceae) is the most frequently used curative herb widely used for kidney obstruction, sciatic pain, and gout. The present study was designed to investigate the therapeutic effects of n\u2010hexane bark extract of\n                    <jats:italic>O. echioides<\/jats:italic>\n                    (OE) L. root in vivo against Streptozotocin\u2010induced diabetic neuropathy in SD rats. For in vivo activity, the experiment was categorized into five different groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095). Group\u2010I was considered as nondiabetic\/normal control (NC) treated with 0.5% carboxymethyl cellulose (CMC), Group II as diabetic control, Group\u2010III, IV, and V served as diabetic treated with OE 50, OE 100, and pregabalin at a dose of 50, 100, and 10\u2009mg\/kg body weight, orally, respectively. Body weight, blood glucose, oral glucose tolerance test, behavioral studies (motor coordination test, thermal hyperalgesia, cold allodynia, locomotor activity, oxidative biomarkers (thio barbituric acid reactive substances [TBARS], superoxide dismutase [SOD], glutathione [GSH], and catalase), and histopathology of the sciatic nerve were performed. Treatment with OE showed a dose\u2010dependent increase in neuroprotective activity by improving the myelination and decreasing the axonal swelling of nerve fibers. The verdicts of behavioral activities showed a remarkable effect on animals after the treatment of extract and standard drug pregabalin. In conclusion, our findings supported the traditional application of OE and explored its importance in the management of diabetic neuropathy. Additional clinical experiments may provide novel therapeutic drugs for diabetes and its complications.\n                  <\/jats:p>","DOI":"10.1002\/jcb.28912","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T05:59:08Z","timestamp":1558072748000},"page":"16524-16532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Beneficial effects of n\u2010hexane bark extract of\n                    <i>Onosma echioides<\/i>\n                    L. on diabetic peripheral neuropathy"],"prefix":"10.1002","volume":"120","author":[{"given":"Ambreen","family":"Shoaib","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy Integral University  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Badruddeen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy Integral University  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh Kumar","family":"Dixit","sequence":"additional","affiliation":[{"name":"Department of Pharmacology King George Medical University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdah","family":"Ganash","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6644-1971","authenticated-orcid":false,"given":"George","family":"Barreto","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bioqu\u00edmica, Facultad de Ciencias Pontificia Universidad Javeriana  Bogot\u00e1 D.C Colombia"},{"name":"Instituto de Ciencias Biom\u00e9dicas Universidad Aut\u00f3noma de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9820-2078","authenticated-orcid":false,"given":"Ghulam Md","family":"Ashraf","sequence":"additional","affiliation":[{"name":"King Fahd Medical Research Center King Abdulaziz University  Jeddah Saudi Arabia"},{"name":"Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hefazat Hussain","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy Integral University  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,17]]},"reference":[{"key":"e_1_2_9_1_2_1","first-page":"449","article-title":"Current pharmacotherapeutics approaches to treat diabetic neuropathy","volume":"8","author":"Shoaib A","year":"2016","journal-title":"J Chem Pharm Res"},{"key":"e_1_2_9_1_3_1","first-page":"38","article-title":"Medicinal plants folklore and ayurvedic system of medicine in the Indo\u2010Tibetan outer Himalayas","volume":"75","author":"Sharma G","year":"2000","journal-title":"J Tenn Acad Sci"},{"key":"e_1_2_9_1_4_1","first-page":"534","volume-title":"Compendium of Medicinal Plants in Nepal","author":"Baral SR","year":"2006"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-4269-2-41"},{"key":"e_1_2_9_1_6_1","first-page":"1356","article-title":"Psychoimmunomodulatory effects of Onosma bracteatum Wall. 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