{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:21:49Z","timestamp":1790990509976,"version":"4.1.0"},"reference-count":98,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T00:00:00Z","timestamp":1558310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772409"],"award-info":[{"award-number":["81772409"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The nature of muscle\u2010bone crosstalk has been historically considered to be only mechanical, where the muscle is the load applier while bone provides the attachment sites. However, this dogma has been challenged with the emerging notion that bone and muscle act as secretory endocrine organs affect the function of each other. Biochemical crosstalk occurs through myokines such as myostatin, irisin, interleukin (IL)\u20106, IL\u20107, IL\u201015, insulin\u2010like growth factor\u20101, fibroblast growth factor (FGF)\u20102, and \u03b2\u2010aminoisobutyric acid and through bone\u2010derived factors including FGF23, prostaglandin E\n                    <jats:sub>2<\/jats:sub>\n                    , transforming growth factor \u03b2, osteocalcin, and sclerostin. Aside from the biochemical and mechanical interaction, additional factors including aging, circadian rhythm, nervous system network, nutrition intake, and exosomes also have effects on bone\u2010muscle crosstalk. Here, we summarize the current research progress in the area, which may be conductive to identify potential novel therapies for the osteoporosis and sarcopenia, especially when they develop in parallel.\n                  <\/jats:p>","DOI":"10.1002\/jcb.28946","type":"journal-article","created":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T04:49:10Z","timestamp":1558327750000},"page":"14262-14273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":157,"title":["Muscle\u2010bone crosstalk and potential therapies for sarco\u2010osteoporosis"],"prefix":"10.1002","volume":"120","author":[{"given":"GuoBin","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences Northwestern Polytechnical University Xi'an Shaanxi 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