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In the current meta\u2010analysis, we aimed to evaluate the association between the <jats:italic>ACE<\/jats:italic> Gene insertion\/deletion (I\/D) polymorphism (<jats:italic>DD<\/jats:italic> vs <jats:italic>II<\/jats:italic>) and digestive system cancer susceptibility. A total of 19 case\u2010control studies among 3722 patients with seven different types of cancer were included in this meta\u2010analysis. In the pooled analysis, the relationship between the <jats:italic>ACE<\/jats:italic> I\/D polymorphism and digestive system cancer risk was not statistically significant (odds ratio [OR], 0.93; 95% confidence interval [CI], 0.68\u20101.29; <jats:italic>P<\/jats:italic>\u2009=\u20090.65; random model). Furthermore, subgroup analyses by cancer type also did not reveal an association between <jats:italic>ACE<\/jats:italic> polymorphisms and colorectal cancer (OR, 1.14; 95% CI, 0.823\u20101.58; <jats:italic>P<\/jats:italic>\u2009=\u20090.43; random effect model) and gastric cancer (OR, 0.79; 95% CI, 0.51\u20101.22; <jats:italic>P<\/jats:italic>\u2009=\u20090.28; random effect model). These findings indicate that <jats:italic>ACE<\/jats:italic> polymorphisms in the digestive tract may still affect the survival of cancer patients, and future studies into the topic of effect of ACE on cancer prognosis are warranted.<\/jats:p>","DOI":"10.1002\/jcb.28955","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T07:00:07Z","timestamp":1567494007000},"page":"19388-19395","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Angiotensin\u2010converting enzyme gene polymorphism and digestive system cancer risk: A meta\u2010analysis based on 9656 subjects"],"prefix":"10.1002","volume":"120","author":[{"given":"Hossein","family":"Abdeahad","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry Faculty of Medicine, Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4968-0962","authenticated-orcid":false,"given":"Amir","family":"Avan","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Department of Modern Sciences and Technologies Faculty of Medicine, Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Khazaei","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Department of Medical Physiology, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saman","family":"Soleimanpour","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Virology, School of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon A.","family":"Ferns","sequence":"additional","affiliation":[{"name":"Brighton &amp; 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