{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T09:30:21Z","timestamp":1786354221365,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T00:00:00Z","timestamp":1558224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T00:00:00Z","timestamp":1558224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"National Science and Technology Major Project of the Ministry of Science and Technology of China","award":["2018ZX10732202"],"award-info":[{"award-number":["2018ZX10732202"]}]},{"name":"Basic research and frontier exploration project of Yuzhong District of Chongqing","award":["20180109"],"award-info":[{"award-number":["20180109"]}]},{"name":"Leading Talent Program of CQCSTC","award":["CSTCCXLJRC201719"],"award-info":[{"award-number":["CSTCCXLJRC201719"]}]},{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of CQ CSTC","doi-asserted-by":"crossref","award":["cstc2018jcyjAX0751"],"award-info":[{"award-number":["cstc2018jcyjAX0751"]}],"id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The dysregulation of long\u2010chain noncoding ribonucleic acid (lncRNA) is a common phenomenon in many human cancers. Some studies on the biological function of long intergenic non\u2010protein\u2010coding RNA 52 (LINC00052) in cancer indicate that this gene can act as either oncogene or tumor suppressor in some kinds of cancers, such as breast cancer, gastric cancer, liver cancer, and lung cancer. However, the biological function of LINC00052 in colorectal cancer (CRC) has not been studied. Quantitative reverse\u2010transcription polymerase chain reaction (qRT\u2010PCR) and Western blot (WB) techniques were applied to detect the expression levels of LINC00052, miR\u2010574\u20105p, and calcium\u2010binding and coiled\u2010coil domain 1 (CALCOCO1) in CRC cells and tissues. We authenticated the biological function of LINC00052 and miR\u2010574\u20105p in CRC, and find some target genes for LINC00052 and miR\u2010574\u20105p via bioinformatics methods. Dual\u2010luciferase reporter gene assay was performed to identify the interaction between LINC00052 and miR\u2010574\u20105p or CALCOCO1 and miR\u2010574\u20105p. The results demonstrated that LINC00052 was downregulated in CRC tissues compared with their adjacent tissues. And LINC00052 could suppress CRC cells metastasis both in vivo and in vitro. Beyond that, miR\u2010574\u20105p was upregulated in CRC tissues, and as an oncogene, it accelerated CRC cell migration and invasion. More importantly, the results of our research demonstrated that LINC00052 could regulate the expression of CALCOCO1 via sponging miR\u2010574\u20105p in CRC. Overall, our study illuminated the lncRNA\u2010miRNA functional networks in CRC, and these results might provide a new research direction for the diagnosis and treatment of CRC.<\/jats:p>","DOI":"10.1002\/jcb.28988","type":"journal-article","created":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T04:29:54Z","timestamp":1558240194000},"page":"17258-17272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["<i>Retracted<\/i>\n                    : Long noncoding RNA LINC00052 inhibits colorectal cancer metastasis by sponging microRNA\u2010574\u20105p to modulate CALCOCO1 expression"],"prefix":"10.1002","volume":"120","author":[{"given":"Gangfeng","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Xiong","sequence":"additional","affiliation":[{"name":"Nursing Department Chongqing Medical and Pharmaceutical College  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengshu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physical Examination he First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongguo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5757-4123","authenticated-orcid":false,"given":"Hua","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University  Chongqing 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