{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T09:30:35Z","timestamp":1786354235552,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Primary Sj\u00f6gren's syndrome (pSS) is a chronic systemic autoimmune disease that affects exocrine glands. To study the molecular mechanism and identify crucial genes\/pathways in pSS pathogenesis, the microarray\u2010based whole\u2010genome gene expression profiles from salivary glands of patients with pSS and non\u2010sicca controls were retrieved. After normalization and subsequent batch effect adjustment, significance analysis of microarrays method was applied to five available datasets, and 379 differentially expressed genes (DEGs) were identified. The 300 upregulated DEGs were enriched in Gene Ontology terms of immune and inflammatory responses, including antigen processing and presentation, interferon\u2010mediated signaling pathway, and chemotaxis. Previously reported pSS\u2010associated genes, including HLA\u2010DRA, TAP2, PRDM1, and IFI16, were found to be significantly upregulated. The downregulated DEGs were enriched in pathways of salivary secretion, carbohydrate digestion and absorption, and starch and sucrose metabolism, implying dysfunction of salivary glands during pathogenesis. Next, a protein\u2010protein interaction network was constructed, and B2M, an upregulated DEG, was shown to be a hub, suggesting its potential involvement in pSS development. In summary, we found the activation of pSS\u2010associated genes in pathogenesis, and provide clues for salivary glands dysfunction. Experimental investigation on the identified DEGs in this study will deepen our understanding on pSS.<\/jats:p>","DOI":"10.1002\/jcb.29001","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T11:35:09Z","timestamp":1558697709000},"page":"17368-17377","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Identification of differentially expressed genes in primary Sj\u00f6gren's syndrome"],"prefix":"10.1002","volume":"120","author":[{"given":"Lei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Fuwai Central China Cardiovascular Hospital  Zhengzhou Henan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3973-7996","authenticated-orcid":false,"given":"Poshi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Fuwai Central China Cardiovascular 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