{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:03:45Z","timestamp":1790291025214,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["15202"],"award-info":[{"award-number":["15202"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,10]]},"abstract":"Abstract<\/jats:title>\n \n The brain\u2010derived neurotrophic factor (BDNF) is a certain type of growth factor that participates in the correct construction of the brain. Moreover, some reports have shown its participation in the tumorigenesis process. A long noncoding RNA known as\n BDNF\u2010antisense<\/jats:italic>\n (\n BDNF<\/jats:italic>\n \u2010\n AS<\/jats:italic>\n ) is shown to be transcribed from the antisense direction of the\u00a0\n BDNF<\/jats:italic>\n gene and control its expression. In the current study, we compared expression levels of\n BDNF<\/jats:italic>\n and its antisense in gastric cancer tissues and adjacent noncancerous tissues (ANCTs) using quantitative real\u2010time polymerase chain reaction. Expression of both genes tended to decrease in gastric cancer tissues in comparison with ANCTs (expression ratio\u2009=\u20090.4 and\n P<\/jats:italic>\n \u2009=\u2009.06 for\n BDNF<\/jats:italic>\n ; expression ratio\u2009=\u20090.35 and\n P<\/jats:italic>\n \u2009=\u2009.05 for\n BDNF\u2010AS<\/jats:italic>\n , respectively). Relative transcript levels of both genes were remarkably associated with the site of primary tumor in a way that all cardia tumors had low levels of both\n BDNF<\/jats:italic>\n and\n BDNF\u2010AS<\/jats:italic>\n in comparison with their paired ANCTs (\n P<\/jats:italic>\n \u2009=\u2009.002 and\n P<\/jats:italic>\n \u2009=\u2009<.001). We also found higher amounts of both genes in malignant samples obtained from older patients (\n P<\/jats:italic>\n \u2009=\u2009.01 and\n P<\/jats:italic>\n \u2009=\u2009.03 for\n BDNF<\/jats:italic>\n and\n BDNF\u2010AS<\/jats:italic>\n , respectively). Besides,\n BDNF<\/jats:italic>\n expression was higher in tumors with lymphatic\/vascular invasion (\n P<\/jats:italic>\n \u2009=\u2009.01). There was also a trend toward upregulation of\n BDNF\u2010AS<\/jats:italic>\n in tumors with lymphatic\/vascular invasion (\n P<\/jats:italic>\n \u2009=\u2009.05). The current study underscores the role of\n BDNF<\/jats:italic>\n and\n BDNF\u2010AS<\/jats:italic>\n in the pathogenic process leading to gastric cancer.\n <\/jats:p>","DOI":"10.1002\/jcb.29050","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T02:35:08Z","timestamp":1559874908000},"page":"17831-17837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Brain\u2010derived neurotrophic factor downregulation in gastric cancer"],"prefix":"10.1002","volume":"120","author":[{"given":"Farbod","family":"Esfandi","sequence":"first","affiliation":[{"name":"Department of Medical Genetics Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Bouraghi","sequence":"additional","affiliation":[{"name":"Department of Health Information Technology, School of Paramedical Sciences Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C","family":"Glassy","sequence":"additional","affiliation":[{"name":"Translational Neuro\u2010Oncology Laboratory, UCSD Moores Cancer Center University of California La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8381-0591","authenticated-orcid":false,"given":"Mohammad","family":"Taheri","sequence":"additional","affiliation":[{"name":"Urogenital Stem Cell Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mir Salar","family":"Kahaei","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Kholghi Oskooei","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0223-499X","authenticated-orcid":false,"given":"Soudeh","family":"Ghafouri\u2010Fard","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.11783"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2016.3628"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.39"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3333"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/cbm\u2010130345"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2158"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.01.134"},{"key":"e_1_2_8_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.03.118"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.499"},{"key":"e_1_2_8_1_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2000.107265"},{"issue":"2","key":"e_1_2_8_1_12_1","first-page":"e1566","article-title":"Brain derived neutrophic factor (BDNF) coordinates lympho\u2010vascular metastasis through a fibroblast\u2010governed paracrine axis in the tumor microenvironment","volume":"4","author":"Jiffar T","year":"2017","journal-title":"Cancer Cell Microenviron"},{"key":"e_1_2_8_1_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.143.11.1062"},{"key":"e_1_2_8_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010005\u20107935\u20105"},{"key":"e_1_2_8_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2005.05.009"},{"key":"e_1_2_8_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mgene.2018.10.012"}],"container-title":["Journal of Cellular 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