{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:36:53Z","timestamp":1792255013634,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["grant no. 9124"],"award-info":[{"award-number":["grant no. 9124"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We examined the effects of photobiomodulation (PBM) independently and combined with curcumin on stereological parameters and basic fibroblast growth factor (\n                    <jats:italic>bFGF<\/jats:italic>\n                    ), hypoxia\u2010inducible factor\u20101\u03b1 (\n                    <jats:italic>HIF\u20101\u03b1<\/jats:italic>\n                    ), and stromal cell\u2010derived factor\u20101\u03b1 (\n                    <jats:italic>SDF\u20101\u03b1<\/jats:italic>\n                    ) gene expressions in an excisional wound model of rats with type one diabetes mellitus (T1DM). T1DM was induced by an injection of streptozotocin (STZ) in each of the 90 male Wistar rats. One round excision was generated in the skin on the back of each of the 108 rats. The rats were divided into six groups (n\u2009=\u200918 per group): control (diabetic), untreated group; vehicle (diabetic) group, which received sesame oil; PBM (diabetic) group; curcumin (diabetic) group; PBM\u2009+\u2009curcumin (diabetic) group; and a healthy control group. On days 4, 7, and 15, we conducted both stereological and quantitative real\u2010time PCR (qRT\u2010PCR) analyses. The PBM and PBM\u2009+\u2009curcumin groups had significantly better inflammatory response modulation in terms of macrophages (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.01), neutrophils (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001), and increased fibroblast values compared with the other groups at day 4 (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001), day 7 (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.01), and day 15 (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001). PBM treatment resulted in increased\n                    <jats:italic>bFGF<\/jats:italic>\n                    gene expression on days 4 (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001) and 7 (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001), and\n                    <jats:italic>SDF\u20101\u03b1<\/jats:italic>\n                    gene expression on day 4 (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001). The curcumin group had increased\n                    <jats:italic>bFGF<\/jats:italic>\n                    (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001) expression on day 4. Both the PBM and PBM\u2009+\u2009curcumin groups significantly increased wound healing by modulation of the inflammatory response, and increased fibroblast values and angiogenesis. The PBM group increased\n                    <jats:italic>bFGF<\/jats:italic>\n                    and\n                    <jats:italic>SDF\u20101\u03b1<\/jats:italic>\n                    according to stereological and gene expression analyses compared with the other groups. The PBM and PBM\u2009+\u2009curcumin groups significantly increased the skin injury repair process to\u00a0more rapidly reach\u00a0the proliferation phase of the wound healing in T1DM rats.\n                  <\/jats:p>","DOI":"10.1002\/jcb.29102","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:42:03Z","timestamp":1559263323000},"page":"17994-18004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Stereological and gene expression examinations on the combined effects of photobiomodulation and curcumin on wound healing in type one diabetic rats"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1845-3924","authenticated-orcid":false,"given":"Abdollah","family":"Amini","sequence":"first","affiliation":[{"name":"Department of Biology and Anatomical Sciences, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Soleimani","sequence":"additional","affiliation":[{"name":"Department of Biology and Anatomical Sciences, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6947-3285","authenticated-orcid":false,"given":"Mohammad\u2010Amin","family":"Abdollhifar","sequence":"additional","affiliation":[{"name":"Department of Biology and Anatomical Sciences, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Moradi","sequence":"additional","affiliation":[{"name":"Department of Biology and Anatomical Sciences, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Kamran","family":"Ghoreishi","sequence":"additional","affiliation":[{"name":"Department of Statistics University of Qom  Qom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufan","family":"Chien","sequence":"additional","affiliation":[{"name":"Price Institute of Surgical Research University of Louisville, and Noveratech LLC of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5214-4223","authenticated-orcid":false,"given":"Mohammad","family":"Bayat","sequence":"additional","affiliation":[{"name":"Price Institute of Surgical Research University of Louisville, and Noveratech LLC of Louisville  Louisville Kentucky USA"},{"name":"Cellular and Molecular Biology Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,30]]},"reference":[{"key":"e_1_2_9_1_2_1","volume-title":"National diabetes statistics report, 2017","author":"Control Cf D","year":"2017"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.17118.1"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2482-8-5"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970\u20100358.197238"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071419"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/1677\u20105449.010717"},{"key":"e_1_2_9_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-013-0518-7"},{"key":"e_1_2_9_1_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.2.217"},{"key":"e_1_2_9_1_10_1","doi-asserted-by":"publisher","DOI":"10.47102\/annals-acadmedsg.V46N11p417"},{"key":"e_1_2_9_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0690(03)00035-1"},{"key":"e_1_2_9_1_12_1","doi-asserted-by":"publisher","DOI":"10.2119\/2006-00054.Brem"},{"key":"e_1_2_9_1_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0309364614534296"},{"issue":"2","key":"e_1_2_9_1_14_1","first-page":"58","article-title":"Biological effects of low level laser therapy","volume":"5","author":"Farivar S","year":"2014","journal-title":"J Lasers Med Sci"},{"key":"e_1_2_9_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010017\u20102429\u2010x"},{"key":"e_1_2_9_1_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2008.2450"},{"key":"e_1_2_9_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2012.03.001"},{"key":"e_1_2_9_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010017\u20102230\u2010x"},{"key":"e_1_2_9_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010013\u20101500\u20105"},{"key":"e_1_2_9_1_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010017\u20102430\u20104"},{"key":"e_1_2_9_1_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2009.2680"},{"key":"e_1_2_9_1_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2013.0506"},{"issue":"11","key":"e_1_2_9_1_23_1","first-page":"2032","article-title":"A review of therapeutic effects of curcumin","volume":"19","author":"Noorafshan A","year":"2013","journal-title":"Curr Pharm Des"},{"key":"e_1_2_9_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.08.016"},{"key":"e_1_2_9_1_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389201017666160721123109"},{"key":"e_1_2_9_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28273"},{"key":"e_1_2_9_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2018.03.010"},{"key":"e_1_2_9_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26759"},{"key":"e_1_2_9_1_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2016.4191"},{"key":"e_1_2_9_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2018.02.023"},{"key":"e_1_2_9_1_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010018\u20102664\u20109"},{"key":"e_1_2_9_1_32_1","doi-asserted-by":"publisher","DOI":"10.5625\/lar.2016.32.3.160"},{"key":"e_1_2_9_1_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091355"},{"key":"e_1_2_9_1_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001699"},{"key":"e_1_2_9_1_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29710"},{"key":"e_1_2_9_1_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u2010475X.2008.00410.x"},{"key":"e_1_2_9_1_37_1","doi-asserted-by":"publisher","DOI":"10.1248\/jhs.54.432"},{"key":"e_1_2_9_1_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.10.5672"},{"key":"e_1_2_9_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.10.056"},{"key":"e_1_2_9_1_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010018\u20102559\u20109"},{"key":"e_1_2_9_1_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2015.4020"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.29102","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.29102","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcb.29102","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.29102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T08:48:07Z","timestamp":1786351687000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.29102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,30]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1002\/jcb.29102"],"URL":"https:\/\/doi.org\/10.1002\/jcb.29102","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,30]]},"assertion":[{"value":"2018-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}