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However, oxaliplatin\u2010induced peripheral neurotoxicity (OIPN) has a high incidence, and to date, there have been few detailed studies on pathogenesis and treatment mechanisms. The present study was performed by using a proteomic approach to explore protein expression profiling of rats treated with oxaliplatin by multiplex isobaric tags for relative and absolute quantification labeling and two\u2010dimensional liquid chromatography\u2010tandem mass spectrometry. There were 74 proteins that showed different expression in sciatic nerve between control rats and OIPN model rats, with 53 upregulated proteins and 21 downregulated proteins detected in OIPN groups compared with control groups. On the basis of Gene Ontology clustering, these proteins were associated with biological processes (eg, muscle contraction, muscle system process, and skeletal muscle contraction), cellular component (eg, myofibril, contractile fiber, and contractile fiber part) and molecular function (structural constituent of muscle, hydro\u2010lyase activity, and calcium ion binding). On the basis of Kyoto Encyclopedia of Genes and Genomes pathway database, these proteins were associated with African trypanosomiasis, malaria, nitrogen metabolism, etc. Real\u2010time polymerase chain reaction, Western blot as well as immunohistochemistry analysis was performed to examine the expression of partially differential protein. In conclusion, our study establishes a protein expression profile of oxaliplatin\u2010induced rats and mechanisms leading to OIPN development, and will be useful for developing novel diagnostic biomarkers and aiding in the prevention and control of OIPN.<\/jats:p>","DOI":"10.1002\/jcb.29116","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T16:16:30Z","timestamp":1561479390000},"page":"18128-18141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Differential protein expression profiling by iTRAQ\u20102D\u2010LC\u2010MS\/MS of rats treated with oxaliplatin"],"prefix":"10.1002","volume":"120","author":[{"given":"Xianjun","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Integrative Medicine, Huashan Hospital Fudan University  Shanghai China"},{"name":"Qingpu Chinese Medicine Hospital Institutes of Integrative Medicine, Fudan University  Shanghai 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