{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:16:59Z","timestamp":1740104219181,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T00:00:00Z","timestamp":1562803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nuclear factor\u2010\u03baB (NF\u2010\u03baB) is an important regulatory factor in cells. NF\u2010\u03baB has a wide range of biological activities. After activation, it participates in the transcription and regulation of many genes and plays a role in infection, inflammatory response, oxidative stress, cell multiplication, and apoptosis. The activation of the NF\u2010\u03baB signal pathway is dependent on the degradation of the I\u03baB kinase \u03b2 (IKK\u03b2) complex. IKK \u03b2 is the key kinase in the NF\u2010\u03baB activation pathway. After inhibition, it can block the activation of NF\u2010\u03baB. IKK\u03b2 is a key regulator of NF\u2010\u03baB activation, also an early regulator of inflammation in all stages of the immune response. This study aimed to investigate the effect of IKK\u03b2\u2010siRNA lentivirus vector treatment for hepatic fibrosis of rats. An IKK\u03b2\u2010siRNA expression plasmid was constructed and injected in the tail vein of rats. Then, IKK\u03b2\u2010siRNA distribution in the liver was observed by immunofluorescence, and the quantitative polymerase chain reaction was used to detect inflammation\u2010related and fibrosis\u2010related factors. IKK\u03b2\u2010siRNA lentiviruses could be delivered to the liver and significantly decrease carbon tetrachloride\u2010induced hepatic fibrosis. Furthermore, serum transaminase levels significantly decreased, and inflammation\u2010related and fibrosis\u2010related factors decreased. IKK\u03b2\u2010siRNA can be an effective method of anti\u2010fibrosis gene therapy for liver fibrosis.<\/jats:p>","DOI":"10.1002\/jcb.29209","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T06:16:22Z","timestamp":1562912182000},"page":"18894-18900","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective effect of RNA interference targeting Ikk\u03b2 on hepatic fibrosis in rats"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8441-2317","authenticated-orcid":false,"given":"Shi\u2010Fang","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Infectious Disease Lanzhou First People's Hospital  Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Jun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Hospital of Pulmonary Division of 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